Course Coordinator: Assistant Professor Guillaume Thibault (email: Thibault@ntu.edu.sg)
Co-coordinator: Assistant Professor Wang Xiaomeng, LKCSoM (email: WangXiaomeng@ntu.edu.sg )
Academic Unit: 3 AU
Availability: Semester 2
Course Type: BS-Major-PE, BMS-Major-PE
Language of instruction: English
Teaching hours: Tutorials: 39 hours
Learning Objective: This course aims to introduce students to the different steps proteins are engaged through the secretory and endocytic pathways. Students will learn detailed molecular processes part of the secretory and endocytic pathways. The ultimate goal of this course is to make students grasp the fine line between cellular homeostasis and cellular states leading to the development of diseases from secreted and membrane proteins.
Content: This course will cover the molecular details of the secretory and endocytic pathways as secreted and membrane proteins are transported and modified from their site of synthesis in the endoplasmic reticulum (ER) to the plasma membrane or sorted to intracellular organelles. Specific topics covered will include protein translocation into the ER, protein quality control in the ER, ER stress response, vesicle transport from ER to plasma membrane, regulated secretion, and basic concept in endocytosis. An emphasis on related diseases will be covered throughout the different topics.
Students successfully completing this course will be able to:
- Understand the fine balance between homeostasis and defects leading to disease states from secreted and membrane proteins
- Grasp the important role of different stress responses to maintain the flow in protein trafficking
- Discuss current key areas of research related to protein trafficking
Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff. Molecular Biology of the Cell, 6th Edition, Garland Science, 2014, ISBN: 9780815344322
*Prerequisites for Incoming Exchange Students: Equivalent of Year 2 or Higher Biology or Biotechnology Major