Curriculum & Course Descriptions

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BS3017 Advanced Microbial Pathogenesis

Course Coordinator: Asst Prof Kimberly Kline (email: KKline@ntu.edu.sg)

Academic Unit: 3 AU

Availability: Semester 2

Pre-requisite: BS2002,BS2007 
                         (Preferably for students who have obtained at least a ‘B’ grade for both courses)

Course Type: BS-Major-PE

Language of instruction: English

Teaching hours: Lectures: 28 hours; Tutorials: 9 hours; Practicals: 6 hours

Learning Objective: Learn the general molecular and structural principles by which bacteria cause disease.
Gain familiarity with software used to analyse structural interactions important for microbial pathogenesis.
Understand how seminal discoveries in bacterial pathogenesis arose, using primary scientific literature as source material.
Appreciate the current “state of the field” based on the latest primary literature.
Critically analyse different approaches of studying bacterial pathogens.
Apply the scientific method to address open questions in the field of bacterial pathogenesis.

Content:

  • Immune Responses to Infection
  • Microbial Immune Evasion and Survival Strategies
  • Microbial Genetics, Regulation, and Evolution
  • Microbial Virulence Factors
  • Opportunistic Pathogens
  • Foodborne Pathogens

Learning Outcome: At the end of the course, you will have an in-depth understanding of both the molecular and structural mechanisms by which microbial pathogens cause disease. You will understand and appreciate the path of scientific advancement in the field of microbial pathogenesis, from historical observations to the most recent discoveries. You will be able to read, think critically, and discuss primary scientific literature about bacterial pathogens.

Required Textbooks: Bacterial Pathogenesis: A Molecular Approach, ASM Press (current edition), electronic or print version

Supplemental Resources:Antibiotics: Actions, Origins, Resistance by Christopher Walsh, ASM Press (current edition) Primary literature as assigned

*Prerequisites for Incoming Exchange Students:Equivalent of Year 2 or Higher Biology or Biotechnology Major