Curriculum & Course Descriptions

Share     

BS2012 Genetics and Genomics

Course Coordinator:  Asst Prof Amartya Sanyal (email: asanyal@ntu.edu.sg)
 
Academic Unit: 3 AU

Availability: Semester 2

Pre-requisite: None (AY15-16 and before);  BS1006 Principles of Genetics (with effect from AY16-17 Sem2)

Course Type: BS-Major-PE

Language of instruction: English

Teaching hours:  Lectures: 26 hours; Tutorials: 12 hours

Learning Objective: The course will be divided into 12 topics each of which will introduce one concept of genetics and all terminology associated with that. Since this course will be deliver by a series of lectures and tutorials with a structured content based on the 12 topics. The main goal is to grasp the concepts of both classic genetics and well as genome-wide approaches that stem from them. The content of the course will journey from mappings of genetic diseases to genetics of the world population, and complex genetic traits to model organisms and high throughput genetics, and finally to practical applications such as personalized medicine, disease diagnostics and genetic metagenomic surveys.

Content:

  • Basic concepts and principles of genetics and heredity (I): Mendelian genetics
  • Basic concepts of genetics and heredity (II): non-Mendelian inheritance and variation
  • From genes to chromosomes: chromosome structure and anomalies, gene linkage, recombination and chromosomal theory of inheritance
  • Gene mapping and population genetics
  • Gene anatomy
  • Introduction to genomics (I): recombinant DNA technology and basics of DNA sequence analysis
  • Introduction to genomics (II): next-generation sequencing and genome sequence analysis
  • Comparative genomics and genome evolution
  • Genetic studies using model organisms
  • Eukaryotic gene regulation
  • Epigenetics
  • Human genetics, genetic disorders and personalized medicine

Learning Outcome: This course is designed to bring the students from the basic fundamental concepts of genetics to advanced level of knowledge. In particular, this course will bring broader understanding of the genetic elements beyond the “classical genetic dogmas”, genetic concepts beyond the Mendelian laws and breadth of genetic information beyond single gene approaches. Moreover it will introduce modern genetic concepts and technologies including, genome-based studies, large scale genetics and systems biology. One of the goal of this course is to prepare the student for more advanced studies involving the advanced genetics and genomics in the following years.

 
Student Assessment:
Students will be assessed by:
Final 2-hour written examination (60%)
Mid-semester written test (20%)
2 writing assignments (10% + 10%)
 

Textbooks/References

  • L. H. Hartwell, Genetics, from genes to genomes, 5th Edition, McGraw-Hill Education, 2015
  • Robert J Brooker, Genetics, Analysis and Principles, 5th Edition, McGraw-Hill Education, 2015

*Prerequisites for Incoming Exchange Students: Equivalent of A-Level Biology and Biology or Biotechnology major