Curriculum & Course Descriptions

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BS2009 Advanced Biochemistry

Course Coordinator: Associate Professor LIANG Zhao-Xun (email: ZXLiang@ntu.edu.sg)

Academic Unit: 3 AU

Availability: Semester 2

Pre-requisite: BS1005

Course Type: BS-Major-PE

Language of instruction: English

Teaching hours:  Lectures: 25 hours; Tutorials: 12 hours; Practical: 6 hours

Learning Objective: BS2009 is designed to help the students become proficient with the core concepts of modern biochemistry and develop the ability to analyze the structure-function relationship in proteins. Example will be given to expose the students to some of the modern biochemical methods used in the studies of biological macromolecules. The topics related to drug discovery and protein/metabolic engineering will enable the students to develop a deeper appreciation for the biochemical knowledge and logics in drug discovery and enzyme/metabolic engineering.

Content: BS2009 introduces some of the central concepts and topics in modern biochemistry by focusing on the structure and function of protein- and RNA-enzymes. The first half forms the foundation of the module by discussing the fundamental concepts of biochemistry, enzymatic mechanisms and protein structure-function relationship. By discussing some of enzymes related to drug discovery and engineering of enzymes and metabolic pathways, the second half highlights the importance of the analytic skills derived from the biochemical knowledge in pharmaceutical and biotechnology industry. The lectures will emphasize enzymatic mechanism, structure-function relationship, evolutionary relationship and biomedical applications.

Learning Outcome:

  • Students will become proficient with the core concepts of modern biochemistry and develop the ability to analyze the structure-function relationship in proteins.
  • Students will understand some of the modern biochemical methods used in the studies of the structure and function of biological macromolecules.
  • Students will develop a deeper appreciation for the biochemical knowledge and logics in drug discovery and enzyme/metabolic engineering. 

Textbooks/References

  • Principles of Biochemistry by Horton Moran et al, 4th Ed.
  • Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding by Alan Fersht
  •  The Organic Chemistry of Enzyme-Catalyzed Reactions (2nd Ed) by Richard B. Silverman
  •  Principles of Bioinorganic Chemistry by Stephen J. Lippard and Jeremy M. Berg
  •  Enzymatic reaction mechanisms by Perry A. Frey and Adrian D. Hegeman

*Prerequisites for Incoming Exchange Students: Equivalent of A-Level Biology and Biology or Biotechnology major