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Pervushin, Konstantin

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Pervushin, Konstantin

Pervushin, Konstantin
Associate Professor

Office: 02s-77
Telephone: 6514 1916
Email: kpervushin@ntu.edu.sg
Webpage: http://trosylab.sharepoint.com

 

Education

  • M.Sc(Hons, biophysics) Moscow University of Physics and Technology, Russia (1991)
  • PhD Institute of Bioorganic Chemistry, Moscow, Russia (1994)

Professional Experience

  • 1994-1997 Postdoctoral training an the Institut für Molekularbiologie und Biophysik, ETH-Zürich, Supervision Prof. Kurt Wüthrich.
  • 1997 Senior Researcher at the ETH Zürich, laboratory of Prof. Kurt Wüthrich.
  • 2000 Assistant Professor, Laboratorium für Physikalische Chemie, ETH Zurich.

Research Interest

Our laboratory specializes on pulse sequence, software and hardware developments in the area of NMR spectroscopy of diverse biomolecules (mostly nucleic acids and proteins) in solution using Ultra High Field Nuclear Magnetic Resonance technology. Our main focus is development of advanced solution NMR and computational techniques to attack challenging biological problems such as structure/dynamics investigations of membrane proteins, structures of molecular machines assisting folding of other proteins, partially folded proteins serving as molecular models for biological control of protein folding, heme chaperones and large multimeric enzymes. This includes the use of the trans-hydrogen bonds scalar couplings and theoretical quantum chemical calculations for structural refinement of large proteins, novel approaches to detection and assignment of resonances in large proteins using 13C spectroscopy as an alternative to 1H spectroscopy traditionally used in the domain of protein NMR in solution, novel techniques providing access to a large number of dipole-dipole interactions in membrane and large soluble proteins, the use of various forms of spin relaxation as a source of structural information.