- MD and PhD (University of Helsinki, Finland)
- Senior Scientist, University of Basel, Switzerland
- Senior Scientist, Institute for Biomedical Research, Bellinzona, Switzerland
- Permanent scientific Member, Basel Institute for Immunology, Switzerland
- Visiting Scientist, Roche Molecular Biology Nutley, New Jersey, USA
- Postdoctoral Associate, Fox Chase Cancer Center, Philadelphia, USA
All the cells of the blood and immune system are derived ultimately from hematopoietic stem cells (HSC). Therefore, understanding of the rules that govern the maintenance and turn over of HSC is the key to the whole hematopoietic system and especially important to the further improvement of the efficiency of bone marrow (BM) and cord blood transplantations in clinics.
Using in vitro culture systems and genetically modified BM and stromal cells we attempt to build a niche that can support HSC self-renewal and hence provide us unlimited source of HSC for therapeutical purposes. T lymphocytes are the main players in adaptive immunity and the deficiency in their production or function can lead e.g. to dramatic immunodeficiences as exemplified by AIDS and to increasingly more prevalent immune dysfunctions associated in aging.
Since T lymphocytes are generated in thymus we have started to characterize novel genes that are induced and expressed in developing thymocytes. We will use cell biological, genetical, and biochemical approaches in order to understand their roles in T cell development.