|The main emphasis of our research is focused on deciphering the signal transduction pathways of drug resistance and apoptosis as it pertains to in cancer biology. Using novel (TCM herbal extracts) and established chemotherapeutic agents we are currently working on the signal transduction pathways that are crucial for inducing apoptosis in cancer cells. The role of histone deacetylase, prenylation, methylation and acetylation inhibitors are currently being investigated as therapeutic agents in the treatment of a variety of cancers. In addition, putative proto-oncogenic transcription factors, like those of Kruppel-like family of transcription factors are being investigated for their role in tumorgenesis. In trying to decipher signal transduction pathways, we are currently in the process of establishing a first order transcriptional network for these transcription factors. In conjunction with expression profile analysis, we also make use of shRNA libraries, HTS (high-throughput screening) and global transcription factor binding site analysis to answer some of the basic biology underlying drug resistance and apoptosis.