Zhao Yan

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Zhao Yan

Zhao Yan

Lecturer

Office: 03s-62
Telephone: 6514 1901
Email: ZhaoYan@ntu.edu.sg

 

Education

  • M.B.B.S. - Heilongjiang University of Chinese Medicine, PRC
  • Ph.D - Beijing University of Chinese Medicine, PRC

Professional Experience

  • Lecturer, School of Biological Sciences, NTU
  • Adjunct Professor, HeiLongJiang University of Chinese medicine
  • Singapore Registered TCM physician
  • Research Scientist, National University of Singapore
  • Research Fellow,National Cancer Center, Singapore
  • Postdoctoral Fellow,Genome Institute of Singapore
  • Research Scientist, MediPearl Pte Ltd, Singapore
  • Physician & Postdoctoral Fellow, Pathophysiological Laboratory, BUCM, PRC
  • Physician of Internal Medicine, Dong Zhi Men hospital (Affiliated Hospital of BUCM, PRC)
  • Physician of Gynecology, Affiliated Hospital of HLJUCM, PRC
  • Resident Physician of Gynecology,Hospital of Harbin, PRC

Research Interest

The main emphasis of our research is focused on deciphering the signal transduction pathways of drug resistance and apoptosis as it pertains to in cancer biology. Using novel (TCM herbal extracts) and established chemotherapeutic agents we are currently working on the signal transduction pathways that are crucial for inducing apoptosis in cancer cells. The role of histone deacetylase, prenylation, methylation and acetylation inhibitors are currently being investigated as therapeutic agents in the treatment of a variety of cancers. In addition, putative proto-oncogenic transcription factors, like those of Kruppel-like family of transcription factors are being investigated for their role in tumorgenesis. In trying to decipher signal transduction pathways, we are currently in the process of establishing a first order transcriptional network for these transcription factors. In conjunction with expression profile analysis, we also make use of shRNA libraries, HTS (high-throughput screening) and global transcription factor binding site analysis to answer some of the basic biology underlying drug resistance and apoptosis.​ transcript

TCM Research

  • Anti-cancer effects of extracts prepared from Chinese herbal medicines
  • Anti-diabetic effects of extracts prepared from Chinese herbal medicines
  • Toxicity and pharmacokinetic studies on herbal extracts
  • Established in vivo models for senile dementia and ischemia-reperfusion on rats
  • Patho-physiological studies on a new TCM therapy for senile dementia
  • Mechanistic studies on ischemia-reperfusion injury

Clinical Experience

  • Singapore Registered TCM physician
  • Registered Physician (Chinese medicine), China.
  • Majored in Gynecology and Internal Medicine. Guided students in clinical practice and participated as a core member of several clinical projects and trails. Projects included: “Investigation of the theory of Blood-Circulation-Promotion-and-Blood-Stasis-Resolution used as a Therapy for Endometriosis” and “Chinese medical herb ZXTMN on Diabetes and kidney disease”.

Teaching

  • BMS 301 TCM Pharmacology---Lecturer
  • BMS 823, 831, 832, --- Coordinator /Lecturer
  • BMS 101,102, 201,202, 203,204,205, 206,207,302,304,305 and BS 804 ----Coordinator