Wu Bin


Selected Publications


  1. Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor K, Thomas Walz T, Penczek P, Hur S. Molecular imprinting as a signal activation mechanism of the viral RNA sensor RIG-I. Molecular Cell. 2014 Aug 21;55(4):511-23. PMID: 25018021
  2. Peisley A, Wu B, Hui X, Chen ZJ and Hur S. Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature. 2014 May 1; 509:110-114. PMID: 24590070
  3. Peisley A*, Wu B*, Yao H, Walz T and Hur S. RIG-I forms signaling-competent filaments in an ATP-dependent and ubiquitin-independent manner. Molecular Cell. 2013 Sep 12;51(5):573-83.
  4. Wu B, Hur S. Viral counterattack against the host innate immune system. Cell Res. 2013 June, 23 (6), 735-736.
  5. Wu B, Peisley A, Richards C, Yao H, Zeng X, Lin C, Chu F, Walz T and Hur S. Structural Basis for dsRNA recognition, filament formation and antiviral signaling by MDA5. Cell. 2013 Jan 17;152(1-2):276-89.
  6. Peisley A*, Jo M*, Lin C, Wu B, Orme-Johnson M, Walz T, Hohng S & Hur S. Kinetic Mechanism for Viral dsRNA Length Discrimination by MDA5 Filament. U S AProc Natl Acad Sci U S A. 2012:109 (49): 19884-19885.
  7. Chua EY, Vasudevan D, Davey GE, Wu B, Davey CA. The mechanics behind DNA sequence-dependent properties of the nucleosome. Nucleic Acids Research. 2012;40(13):6338-52.
  8. Peisley A, Lin C, Wu B, Orme-Johnson M, Liu M, Walz T, Hur S. Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. U S A.Proc Natl Acad Sci U S A. 2011:108(52):21010-5.
  9. Wu B, Davey GE, Nazarov A, Dyson PJ, Davey CA. Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation. Nucleic Acids Research. 2011;39(18):8200-12.
  10. Wu B, Ong MS, Groessl M, Adhireksan Z, Hartinger CG, Dyson PJ, Davey CA. A ruthenium antimetastasis agent forms specific histone protein adducts in the nucleosome core. Chemistry. 2011;17(13):3562-6.
  11. Wu B, Mohideen K, Vasudevan D, Davey CA. Structural insight into the sequence dependence of nucleosome positioning. Structure. 2010;18(4):528-36.
  12. Wu B, Davey CA. Using soft X-rays for a detailed picture of divalent metal binding in the nucleosome. Journal of Molecular Biology. 2010;398(5):633-40.
  13. Davey GE*, Wu B*, Dong Y, Surana U, Davey CA. DNA stretching in the nucleosome facilitates alkylation by an intercalating antitumour agent. Nucleic Acids Research. 2010;38(6):2081-8.
  14. Wu B, Davey CA. Platinum drug adduct formation in the nucleosome core alters nucleosome mobility butnot positioning. Chemistry & Biology. 2008 Oct 20;15(10):1023-8. PMID: 18940663.
  15. Wu B, Droge P, Davey CA. Site selectivity of platinum anticancer therapeutics. Nature Chemical Biology 2008;4(2):110-2. Profiled in “Research highlight.” Nature. 2008 Jan 10;451:111. PMID: 18157123.