Thanabalu, Thirumaran

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Selected Publications

1) Mitra P, Thanabalu T. (2017) Myogenic differentiation depends on the interplay of Grb2 and N-WASP. Biochim Biophys Acta (BBA) Molecular Cell Research. 1864(3):487-497

2) Salvi A and T Thanabalu (2016) Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter, BBReports

3) Salvi A, Thanabalu T. (2017) WIP promotes in-vitro invasion ability, anchorage independent growth and EMT progression of A549 lung adenocarcinoma cells by regulating RhoA levels. Biochem Biophys Res Commun. 482(4):1353-1359.

4) Jain N, Kalailingam P, Tan KW, Tan HB, Sng MK, Chan JSK, Tan NS and T Thanabalu (2016) Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure, Sci Rep. 6:38109.

5) Jain N, Thanabalu T. (2015) Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α. Sci Rep. 5:15031.

6) Li Y, Jain N, Limpanawat S, To J, Quistgaard EM, Nordlund P, Thanabalu T, Torres J. (2015) Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein. Virology. 482:105-110.

7) Jain N, Tan JH, Feng S, George B, Thanabalu T. (2014) X-linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis. J Biomed Sci.  9;21:91

8) George B, Jain N, Fen Chong P, Hou Tan J, Thanabalu T. (2014) Myogenesis defect due to Toca-1 knockdown can be suppressed by expression of N-WASP. Biochim Biophys Acta. 1843(9):1930-41.

9) Jain N, Lim LW, Tan WT, George B, Makeyev E, Thanabalu T. (2014) Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology. Exp Neurol. 254:29-40. Epub 2014 Jan 23.

10) Jain N, George B, Thanabalu T. (2014) Wiskott-Aldrich Syndrome causing mutation, Pro373Ser restricts conformational changes essential for WASP activity in T-cells. Biochim Biophys Acta. (BBA) Molecular Basis of Disease 1842:623-34.

11) Misra A, Pandey C, Sze SK, T. Thanabalu (2012) Hypoxia activated EGFR signaling induces epithelial to mesenchymal transition (EMT) PLoS One. 7(11):e49766.

12)  Misra A, B George, R Rajmohan, N Jain, MH Wong, R Kambadur and T Thanabalu (2012) Insulin Receptor Substrate protein 53 kDa (IRSp53) is a negative regulator of myogenic differentiation . Int J Biochem Cell Biol 44:928-41.

13) Wong MH, Meng L, Rajmohan R, Yu S, and Thanabalu T (2010) Vrp1p-Las17p interaction is critical for actin patch polarization but is not essential for growth or fluid phase endocytosis in S. cerevisiae. Biochim Biophys Acta. (BBA) Molecular Cell Research 1803(12):1332-46.

14) Misra A, Rajmohan R, Lim RP, Bhattacharyya S, and Thanabalu T (2010) The mammalian verprolin, WIRE induces filopodia independent of N-WASP through IRSp53. Exp Cell Res. 2010 316(17):2810-24.

15) Rajmohan R, A Raodah, MH Wong, and T Thanabalu (2009) Characterization of Wiskott Aldrich Syndrome (WAS) mutants using S. cerevisiae FEMS Yeast Res 9:1226-35.

16) Rajmohan R, MH Wong, L Meng, AL Munn and T Thanabalu (2009) Las17p-Vrp1p but not Las17p-Arp2/3 interaction is important for actin patch polarization in yeast Biochimica et Biophysica Acta (BBA) - (MCR) 1793:825-35.

17) AL Munn and T Thanabalu (2009) Verprolin: a cool set of actin-binding sites and some very HOT prolines. IUBMB Life 61:707-12.

18) Misra A, Lim RP, Wu Z, Thanabalu T (2007) N-WASP plays a critical role in fibroblast adhesion and spreading. Biochem Biophys Res Commun 364:908-12.

19) RP-Z Lim, A  Misra, Z. Wu and T Thanabalu (2007) Analysis of conformational changes in WASP using a split YFP Biochem Biophys Res Commun 362:1085-9.

20) Thanabalu T,  Rajmohan R, Meng L, Ren G, Vajjhala P and AL Munn (2007) Verprolin function in endocytosis and actin organisation:  roles of the Las17p (yeast WASP)-binding domain and a novel C- terminal actin-binding domain FEBS J. 274:4103-25.

21) Meng L, Rajmohan R, S Yu and T Thanabalu (2007) Actin binding and proline rich motifs of CR16 play redundant role in growth of vrp1D cells Biochem Biophys Res Commun 357:289-94.

22) Rajmohan R, Meng L, S Yu and T Thanabalu (2006) WASP suppresses the growth defect of Saccharomyces cerevisiae las17Δ strain in the presence of WIP. Biochem Biophys Res Commun 342:529-36

23) T Thanabalu and AL Munn (2001) Functions of Vrp1p in cytokinesis and actin patches are distinct and neither requires a WH2/V domain EMBO J. 20:6979-6989.

24) Chiou C, EW Davidson, T Thanabalu, AG Porter and JP Allen (1999) Crystallization and preliminary X-ray diffraction studies of the 51 kDa protein of the mosquito-larvicidal binary toxin from Bacillus sphaericus. Acta Crystallogr D Biol Crystallogr 55:1083-1085

25) Thanabalu T, E Koronakis, C Hughes and V Koronakis (1998) Dynamic substrate- dependent bridging of  the energised inner membrane complex to the outer membrane pore during direct in vivo translocation of E.coli HlyA toxin out of the cell. EMBO J.17:6487-6496

26) Wati MR, T Thanabalu, and AG Porter (1997) Gene from tropical Bacillus sphaericus encoding a protease closely related to subtilisins from antarctic bacilli. Biochimica et  Biophysica Acta 1352:56-62

27) Chan SW, T Thanabalu, BY Wee and AG Porter (1996) Unusual Amino Acid Determinants of Host Range in the Mtx2 Family of Mosquitocidal Toxins J. Biol. Chem.  271:14183-14187

28) Liu JW, AG Porter, BY Wee and T Thanabalu (1996) New Gene from Nine Bacillus   sphaericus Strains Encoding Highly Conserved 35.8 kDa Mosquitocidal Toxins Appl. Environ.  Microbiol. 62:2174-2176

29) Thanabalu T, AG Porter and J Hindley (1996) Purification and Identification of a Metabolite from Escherichia coli which is Toxic to Mosquito Larvae J.Invert. Pathol. 67:306-8

30) Thanabalu T and AG Porter (1996) A Bacillus sphaericus gene encoding a novel type of mosquitocidal toxin of 31.8 kDa Gene 170:85-89

31) Liu JW, WH Yap, T Thanabalu and AG Porter (1996) Nature Biotech 14:343-347

32) Thanabalu T and AG Porter (1995) Efficient Expression of a 100-kilodalton Mosquitocidal Toxin in Protease-Deficient Recombinant Bacillus sphaericus Appl. Environ. Microbiol. 61:4031-4036

33) Yap WH, Thanabalu T and AG Porter (1994) Expression of Mosquitocidal Toxin Genes in a Gas-Vacuolated Strain of Ancylobacter aquaticus. Appl. Environ. Microbiol. 60:4199-4202

34) Yap WH, Thanabalu T and AG Porter (1994) Influence of Transcriptional and Translational Control Sequences on the Expression of Foreign Genes in Caulobacter cresentus. J.Bacteriol. 176:2603-2610

35) Thanabalu T,  C Berry and J Hindley (1993) Cytotoxicity and ADP-Ribosylating Activity of the Mosquitocidal Toxin from Bacillus sphaericus SSII-1: Possible Roles of the 27- and 70- Kilodalton peptides. J. Bacteriol. 175:2314-2320

36) Thanabalu T, J Hindley, and C Berry (1992) Proteolytic Processing of the Mosquitocidal Toxin from Bacillus sphaericus SSII-1. J. Bacteriol. 174:5051-5056

37) Thanabalu T, J Hindley, S Brenner, C Oei, and C Berry (1992) Expression of the Mosquitocidal Toxins of Bacillus sphaericus and Bacillus thuringiensis subsp. israelensis by Recombinant Caulobacter crescentus, a Vehicle for Biological Control of Aquatic Insect Larvae. Appl. Environ. Microbiol. 58:905-910

38) Thanabalu T, J Hindley, J Jackson-Yap, and C Berry (1991) Cloning, Sequencing, and Expression of a Gene Encoding a 100-Kilodalton Mosquitocidal Toxin from Bacillus  sphaericus SSII-1. J. Bacteriol. 173:2776-2785