Tan Suet Mien


Selected Publications

  1. Chatterjee, D., D’Souza, A., Zhang, Y., Bin W., Tan, S.M., and Bhattacharjya, S. (2018) Interaction analyses of 14-3-3ζ, Dok1, and phosphorylated integrin β cytoplasmic tails reveal a bi-molecular switch in integrin regulation. J. Mol. Biol. 430, 4419-4430.
  2. Chatterjee, D., Lewis Lu, Z., Tan, S.M.*, and Bhattacharjya, S*. (2018) NMR structure, dynamics and interactions of the integrin β2 cytoplasmic tail with filamin domain IgFLNa21. Sci. Rep., 8, 5490. (*co-correspondance)
  3. Guan, S.Y., Chng, C.P., Ong, L.T., Tan, H.F., Law, S.K.A., and Tan, S.M. (2018) The binding interface of kindlin-2 and ILK involves Asp344/Asp352/Thr356 in kindlin-2 and Arg243/Arg334 in ILK. FEBS Lett, 592, 112-121.
  4. Ong, L.T., Tan, H.F., Feng, C., Qu, J., Loh, S.C., Bhattachariya, S., and Tan, S.M. (2017) The Systemic Lupus Erythematosus associated single nucleotide polymorphism rs1143678 in integrin αM cytoplasmic tail generates a 14-3-3ζ binding site that is proinflammatory. J. Immunol. 198, 883-894.
  5. Feng, C., Wee, W.K., Chen, H., Ong, L.T., Qu, J., Tan, H.F., and Tan, S.M. (2016) Expression of kindlin-3 in melanoma cells impedes cell migration and metastasis. Cell Adh Migr. 7:1-15.
  6. Chong, S.Z., Evrard, M., Devi, S., Chen, J., Lim, J.Y., See, P., Zhang, Y., José M. Adrover, J.M., Lee, B., Tan, L., Li, J.L.Y., Liong, K.H., Phua, C., Balachander, A., Boey, A., Liebl, D., Tan, S.M., Chan, J.K.Y., Balabanian, K., Harris, J.E., Bianchini, M., Weber, C., Duchene, J., Lum, J., Poidinger, M., Chen, Q., Rénia, L., Wang, C., Larbi, A., Randolph, G.J., Weninger, W., Looney, M.R., Krummel, M.F., Biswas, S.K., Ginhoux, F., Hidalgo, A., Bachelerie, F., and Ng, L.G. (2016) CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.  J. Exp. Med. 213:2293-2314.
  7. Chatterjee, D., Zhiping, L.L., Tan, S.M.*, and Bhattacharjya, S*. (2016) Interaction analyses of the integrin β2 cytoplasmic tail with the F3 FERM domain of talin and 14-3-3ζ reveal a ternary complex with phosphorylated tail. J. Mol. Biol. 428:4129-4142. *co-corresponding authors. ​
  8. Guan, S.Y., Tan, S.M., Li, Y., Torres, J., and Law S.K.A. (2016) Function and conformation analyses of an aspartate substitution of the invariant glycine in the integrin βI domain α1-α1′ helixBiochem. Biophy. Rep. 7, 214–217.​
  9. Chua, GL., Tan, S.M.*, Bhattacharjya, S.* (2016) NMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain. PLoS ONE 11(4): e0153501. *co-corresponding authors.​​
  10. Han, J.J., Tan, H.F., Feng C., Wee, W.K., Tee, S.Y., and Tan, S.M. (2016) Data on cell spread area and directional contraction in human umbilical vein endothelial cells on fibronectin and on collagen type I-coated micro-posts. Data Brief. 6, 803-810.
  11. Li, J.L., Lim, C.H., Tay, F.W., Goh, C.C., Devi, S., Malleret, B., Lee, B., Bakocevic, N., Chong, S.Z., Evrard, M., Tanizaki, H., Lim, H.Y., Russell, B., Renia, L., Zolezzi, F., Poidinger, M., Angeli, V., John, A.L., Harris, J.E., Tey, H.L., Tan, S.M., Kabashima, K., Weninger. W., Larbi, A., and Ng. L.G. (2016). Neutrophils self-regulate immune complex-mediated cutaneous inflammation through CXCL2. J. Invest. Dermatol. 136, 416-424.
  12. Qu, J., Ero, R., Feng, C., Ong, L.T., Tan, H.F., Lee, H.S., Ismail, M.H., Bu, W.T., Nama, S., Sampath, P., Gao, Y.G., and Tan, S.M. (2015) Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells. Sci. Rep. 5:18491.
  13. Gupta, S., Chia Y.C.J., Feng, C., Bhunia, A., Tan, S.M., and Bhattacharjya, S. (2015) An alternative phosphorylation switch in integrin ß2 (CD18) tail for Dok1 binding. Sci. Rep. 5, article no. 11630
  14. Ero, R., Dimitrova, V.T., Chen, Y., Bu, W., Feng, S., Liu, T, Wang, P., Xue, C., Tan, S.M., and Gao Y.G. (2015) Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans. Sci. Rep. 5, article no. 8688.
  15. Evrard, M., Chong, S.Z., Devi, S., Chew, W.K., Lee, B., Poidinger, M., Ginhoux, F., Tan, S.M., and Ng, L.G. (2015) Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L-/- reporter mouse by multiphoton intravital microscopy. J. Leukoc. Biol. 97,611-619.
  16. Guan, S., Tan, S.M., Li, Y., Torres, J., Uzel, G., Xiang L., and Law, S.K.A. (2015) Characterization of single amino acid substitutions in the β2 integrin subunit of patients with leukocyte adhesion deficiency (LAD)-1. Blood Cells Mol. Dis. 54,177-182.
  17. Devi, S., Wang, Y., Chew, W.K., Lima, R., A-González, N., Matter, C.N.Z., Chong, S.Z., Schlitzer, A., Bakocevic, N., Chew, S., Keeble, J.L., Goh, C.C., Li J.L.Y., Evrard, M.,Malleret, B., Larbi, A., Renia, L., Haniffa, M., Tan, S.M., Chan, J.K.Y., Balabanian, K., Nagasawa, T., Bachelerie, F., Hidalgo, A., Ginhoux, F., Kubes, P., and Ng, L.G. (2013) Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J. Exp. Med. 210, 2321-36
  18. Setyawati, M.I., Tay, C.Y., Chia, S.L., Goh, S.L., Fang, W., Neo, M.J., Chong, H.C., Tan, S.M., Loo, S.C.J., Ng, K.W., Xie, J.P., Ong, C.N., Tan, N.S., Leong, D.T. (2013) Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin. Nat. Comm. , 4, 1673.
  19. Xue, Z.H., Feng, C., Liu, W.L., Tan, S.M. (2013) A role of kindlin-3 in integrin αMß2 outside-in signaling and the Syk-Vav1-Rac1/Cdc42 signaling axis. PLOS One, 8, e56911.
  20. Chua, G.L., Patra, A.T., Tan, S.M., Bhattacharjya, S. (2013) NMR structure of integrin α4 cytosolic tail and its interactions with paxillin. PLOS One, 8, e55184.
  21. Ho, C.L., Chong, K.S.J., Oppong, J.A., Chuah, M.L.C., Tan, S.M., Liang, Z.X. (2013) Visualizing the perturbation of cellular cyclic di-GMP levels in bacterial cells. J. Am. Chem. Soc. 135, 566-569.
  22. Chua, G.L., Tang X.Y., Patra, A.T., Tan, S.M., Bhattacharjya, S. (2012) Structure and binding interface of the cytosolic tails of αXß2 integrin. PLOS One, 7, e41924.
  23. Feng, C., Li, Y.F., Yau, Y.H., Lee, H.S., Tang, X.Y., Xue, Z.H., Zhou, Y.C., Lim, W.M., Cornvik, T.C., Ruedl, C., Shochat, S.G., Tan, S.M. (2012) Kindlin-3 mediates integrin αLß2 outside-in signaling and it interacts with the scaffold protein receptor for activated-C kinase (RACK1). J. Biol. Chem. 287, 10714-10725 (selected for Faculty of 1000 Biology, 2012)
  24. Tan, S.M. (2012) The leukocyte β2 (CD18) integrins: structure, functional regulation and signaling properties. Biosci. Rep. 32, 241-269
  25. Chua, G.L., Tang, X.Y., Amalraj, M., Tan, S.M., Bhattachariya, S. (2011) Structures and interaction analyses of the integrin αMβ2 cytoplasmic tails. J. Biol. Chem. 286, 43842-43854.
  26. Huang, R.L., Teo, Z., Chong, H.C., Zhu, P., Tan, M.J., Tan, C.K., Lam, C.R., Sng, M.K., Leong, D.T., Tan, S.M., Kersten, S., Ding, J.L., Li, H.Y., Tan, N.S. (2011) ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters. Blood 118, 3990-4002.
  27. Chng, C.P. and Tan, S.M. (2011) Leukocyte integrin αLβ2 transmembrane association dynamics revealed by coarse-grained molecular dynamics simulations. Proteins, 79, 2203-13.
  28. Suck, G., Tan, S.M., Chu S., Niam, M., Vararattanavech, A., Lim, T.J., Koh, M.B.C. (2010) KHYG-1 and NK92 represent different subtypes of LFA-1-mediated NK cell adhsiveness. Front. Biosci. E3, 166-178.
  29. Goh, Y.Y., Pal, M., Chong, H.C., Zhu, P.C., Tan, M.J., Punugu, L., Lam, CRI, Yau, Y.H., Tan, C.K., Huang, R.L., Tan, S.M., Tang, M.B.Y., Ding, J.L., Kersten, S., Tan, N.S. (2010). Angiopoietin-like 4 interacts with integrins ß1 and ß5 to modulate keratinocyte migration. Am. J. Pathol. 177:2791-803.
  30. Vararattanavech, A., Chng, C.P., Parthasarathy, K., Tang, X.Y., Torres, J., Tan, S.M. (2010) A transmembrane polar interaction is involved in the functional regulation of integrin αLβ2. J. Mol. Biol. 398, 569-583.
  31. Xue, Z.H., Zhao, C.Q., Chua, G.L., Tan, S.W., Tang, X.Y., Wong, S.C., Tan, S.M. (2010) Integrin αMβ2 clustering triggers phosphorylation and activation of PKCδ that regulates transcription factor Foxp1 expression in monocytes. J. Immunol. 184, 3697-3709.
  32. Domadia, P.N., Li, Y.F., Bhunia, A., Mohanram, H., Tan, S.M.*, Bhattacharjya, S.* (2010) Functional and structural characterization of the talin F0F1 domain. Biochem. Biophys. Res.       Commun. 391:159-165. (*co-corresponding author)
  33. Bhunia, A., Tang, X.Y., Mohanram, H., Tan, S.M.*, and Bhattacharjya, S.* (2009) NMR solution conformations and interactions of integrin aLb2 cytoplasmic tails. J. Biol. Chem. 284, 3873-3884 (*co-corresponding author)
  34. Vararattanavech, A., Lin, X., Torres, J., and Tan, S.M. (2009) Disruption of the integrin aLb2 transmembrane domain interface by b2Thr686 mutation activates aLb2 and promotes micro-clustering of the aL subunits. J. Biol. Chem.  284, 3239-3249
  35. Tang, M.L., Vararattanavech, A., and Tan, S.M. (2008) uPAR induces conformational changes in the integrin aMb2 headpiece and re-orientation of its transmembrane domains. J. Biol. Chem. 283, 25392-25403.
  36. Tang, X.Y., Li, Y.F., and Tan, S.M. (2008) ICAM-3 binding of integrin aLb2 requires both extension and opening of the integrin headpiece. J. Immunol. 180, 4793-4804.
  37. Vararattanavech A., Tang M.L., Li H.Y., Wong C.H., Law S.K.A., Torres J., and Tan S.M. (2008) Permissive transmembrane heterodimerization is required for the expression of a functional integrin. Biochem. J.410, 495-502.
  38. Parthasarathy, K., Lin, X., Tan, S.M., Law, S.K.A. and Torres, J. (2008) Transmembrane helices that form two opposite homodimeric interactions: an asparagine scan study of αM and β2 integrins. Protein Sci. 17, 1-9.
  39. Tan, S.M.*, and Law, S.K.A. (2008) Cell surface integrins. In Molecular Aspects of Innate and Adaptive immunity. (Ed. KBM Reid & RB Sim) pp.195-216. Royal Society of Chemistry Publishing. London. (* corresponding author)
  40. Shi, M. L., Foo, S.Y., Tan, S.M., Mitchell, E.P., Law, S.K., and Lescar, J. (2007) A structural hypothesis for the transition between bent and extended conformations of the leukocyte b2 integrins. J. Biol. Chem. 282, 30198-30206.
  41. Li, Y.F., Tang, R.H., Puan, K.J., Law, S.K.A., and Tan, S.M. (2007) The cytosolic protein talin induces an intermediate affinity aLb2. J. Biol. Chem. 282, 24310-24319.
  42. Cheng, M., Foo, S.Y., Shi, M.L., Tang, R.H., Kong. L.S.., Law, S.K.A., and Tan, S.M. (2007) Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins      aLb2 and aIIbb3. J. Biol. Chem. 282, 18225-18232.