Sze Siu Kwan, Newman

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Selected Publications

  1. Cheow, E. S. H.; Sim, K. H.; Kleijn, D. d.; Lee, C. N.; Sorokin, V.; Sze, S. K., Simultaneous enrichment of plasma soluble and extracellular vesicular glycoproteins using prolonged ultracentrifugation-ERLIC approach. Molecular & Cellular Proteomics 2015, (In Press).(IF: 7.3)
  2. Dutta, B.; Yan, R.; Lim, S. K.; Tam, J. P.; Sze, S. K., Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis. Mol Cell Proteomics 2014, 13, (12), 3236-49.(IF: 7.3)
  3. Ren, Y.; Hao, P.; Law, S. K.; Sze, S. K., Hypoxia-induced changes to integrin alpha 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431. Mol Cell Proteomics 2014, 13, (11), 3126-37.(IF: 7.3)
  4. Dutta, B.; Ren, Y.; Hao, P.; Sim, K. H.; Cheow, E.; Adav, S.; Tam, J. P.; Sze, S. K., Profiling of the Chromatin-Associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression. Mol Cell Proteomics 2014.(IF: 7.3)
  5. Gunawan, M.; Venkatesan, N.; Loh, J. T.; Wong, J. F.; Berger, H.; Neo, W. H.; Li, L. Y.; La Win, M. K.; Yau, Y. H.; Guo, T.; See, P. C.; Yamazaki, S.; Chin, K. C.; Gingras, A. R.; Shochat, S. G.; Ng, L. G.; Sze, S. K.; Ginhoux, F.; Su, I. H., The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nat Immunol 2015.(IF: 26.2)
  6. Alajem, A.; Biran, A.; Harikumar, A.; Sailaja, B. S.; Aaronson, Y.; Livyatan, I.; Nissim-Rafinia, M.; Sommer, A. G.; Mostoslavsky, G.; Gerbasi, V. R.; Golden, D. E.; Datta, A.; Sze, S. K.; Meshorer, E., Differential Association of Chromatin Proteins Identifies BAF60a/SMARCD1 as a Regulator of Embryonic Stem Cell Differentiation. Cell Rep 2015, 10, (12), 2019-31.(If: 7.2);
  7. Kfir, N.; Lev-Maor, G.; Glaich, O.; Alajem, A.; Datta, A.; Sze, S. K.; Meshorer, E.; Ast, G., SF3B1 Association with Chromatin Determines Splicing Outcomes. Cell Rep 2015.(If: 7.2);
  8. Hao, P.; Sze, S. K., Proteomic analysis of protein deamidation. Curr Protoc Protein Sci 2014, 78, 24.5.1-24.5.14.
  9. Adav, S. S.; Qian, J.; Ang, Y. L.; Kalaria, R. N.; Lai, M. K.; Chen, C. P.; Sze, S. K., iTRAQ quantitative clinical proteomics revealed role of Na(+)K(+)-ATPase and its correlation with deamidation in vascular dementia. J Proteome Res 2014, 13, (11), 4635-46.(IF: 5.1)
  10. Hao, P.; Ren, Y.; Datta, A.; Tam, J. P.; Sze, S. K., Evaluation of the effect of trypsin digestion buffers on artificial deamidation. J Proteome Res 2015, 14, (2), 1308-14.(If: 5.1)
  11. Chong, P. S.; Zhou, J.; Cheong, L. L.; Liu, S. C.; Qian, J.; Guo, T.; Sze, S. K.; Zeng, Q.; Chng, W. J., LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia. Cancer Res 2014, 74, (11), 3043-53.(IF: 8.6)
  12. Li, Z.; Hao, P.; Li, L.; Tan, C. Y.; Cheng, X.; Chen, G. Y.; Sze, S. K.; Shen, H. M.; Yao, S. Q., Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl 2013, 52, (33), 8551-6.(IF: 13.7)
  13. Adav, S. S.; Ravindran, A.; Sze, S. K., Proteomic analysis of temperature dependent extracellular proteins from Aspergillus fumigatus grown under solid-state culture condition. J Proteome Res 2013, 12, (6), 2715-31.(IF: 5.1)
  14. Sundramoorthy, A. K.; Mesgari, S.; Wang, J.; Kumar, R.; Sk, M. A.; Yeap, S. H.; Zhang, Q.; Sze, S. K.; Lim, K. H.; Chan-Park, M. B., Scalable and effective enrichment of semiconducting single-walled carbon nanotubes by a dual selective naphthalene-based azo dispersant. J Am Chem Soc 2013, 135, (15), 5569-81.(IF: 10.7)
  15. Kanhai, D. A.; Visseren, F. L.; van der Graaf, Y.; Schoneveld, A. H.; Catanzariti, L. M.; Timmers, L.; Kappelle, L. J.; Uiterwaal, C. S.; Lim, S. K.; Sze, S. K.; Pasterkamp, G.; de Kleijn, D. P., Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease. Int J Cardiol 2013, 168, (3), 2358-63.(IF: 5.5)
  16. Zhang, L.; Selao, T. T.; Pisareva, T.; Qian, J.; Sze, S. K.; Carlberg, I.; Norling, B., Deletion of Synechocystis sp. PCC 6803 leader peptidase LepB1 affects photosynthetic complexes and respiration. Mol Cell Proteomics 2013, 12, (5), 1192-203.(IF: 7.3)
  17. Ren, Y.; Hao, P.; Dutta, B.; Cheow, E. S.; Sim, K. H.; Gan, C. S.; Lim, S. K.; Sze, S. K., Hypoxia modulates A431 cellular pathways association to tumor radioresistance and enhanced migration revealed by comprehensive proteomic and functional studies. Mol Cell Proteomics 2013, 12, (2), 485-98.(IF: 7.3)
  18. Guo, T.; Fan, L.; Ng, W. H.; Zhu, Y.; Ho, M.; Wan, W. K.; Lim, K. H.; Ong, W. S.; Lee, S. S.; Huang, S.; Kon, O. L.; Sze, S. K., Multidimensional identification of tissue biomarkers of gastric cancer. J Proteome Res 2012, 11, (6), 3405-13.(IF: 5.1)
  19. Li, X.; Arslan, F.; Ren, Y.; Adav, S. S.; Poh, K. K.; Sorokin, V.; Lee, C. N.; de Kleijn, D.; Lim, S. K.; Sze, S. K., Metabolic adaptation to a disruption in oxygen supply during myocardial ischemia and reperfusion is underpinned by temporal and quantitative changes in the cardiac proteome. J Proteome Res 2012, 11, (4), 2331-46.(IF: 5.1)
  20. Adav, S. S.; Chao, L. T.; Sze, S. K., Quantitative secretomic analysis of Trichoderma reesei strains reveals enzymatic composition for lignocellulosic biomass degradation. Mol Cell Proteomics 2012, 11, (7), M111.012419.(IF: 7.3)
  21. Mukherjee, M.; Chow, S. Y.; Yusoff, P.; Seetharaman, J.; Ng, C.; Sinniah, S.; Koh, X. W.; Asgar, N. F.; Li, D.; Yim, D.; Jackson, R. A.; Yew, J.; Qian, J.; Iyu, A.; Lim, Y. P.; Zhou, X.; Sze, S. K.; Guy, G. R.; Sivaraman, J., Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. Embo j 2012, 31, (5), 1308-19.(IF: 9.8)
  22. Hao, P.; Qian, J.; Dutta, B.; Cheow, E. S.; Sim, K. H.; Meng, W.; Adav, S. S.; Alpert, A.; Sze, S. K., Enhanced separation and characterization of deamidated peptides with RP-ERLIC-based multidimensional chromatography coupled with tandem mass spectrometry. J Proteome Res 2012, 11, (3), 1804-11.(IF: 5.1)
  23. Hao, P.; Ren, Y.; Alpert, A. J.; Sze, S. K., Detection, evaluation and minimization of nonenzymatic deamidation in proteomic sample preparation. Mol Cell Proteomics 2011, 10, (10), O111.009381.(IF: 7.3)
  24. Choi, Y. K.; Liu, P.; Sze, S. K.; Dai, C.; Qi, R. Z., CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. J Cell Biol 2010, 191, (6), 1089-95.(IF: 10.8)
  25. Peeters, W.; de Kleijn, D. P.; Vink, A.; van de Weg, S.; Schoneveld, A. H.; Sze, S. K.; van der Spek, P. J.; de Vries, J. P.; Moll, F. L.; Pasterkamp, G., Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events. Eur Heart J 2011, 32, (14), 1758-68.(IF: 14.1)
  26. Guo, T.; Lee, S. S.; Ng, W. H.; Zhu, Y.; Gan, C. S.; Zhu, J.; Wang, H.; Huang, S.; Sze, S. K.; Kon, O. L., Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome. Cell Mol Life Sci 2011, 68, (11), 1983-2002.(IF: 5.6)
  27. Guo, T.; Zhu, Y.; Gan, C. S.; Lee, S. S.; Zhu, J.; Wang, H.; Li, X.; Christensen, J.; Huang, S.; Kon, O. L.; Sze, S. K., Quantitative proteomics discloses MET expression in mitochondria as a direct target of MET kinase inhibitor in cancer cells. Mol Cell Proteomics 2010, 9, (12), 2629-41.(IF: 7.3)
  28. Park, J. E.; Tan, H. S.; Datta, A.; Lai, R. C.; Zhang, H.; Meng, W.; Lim, S. K.; Sze, S. K., Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol Cell Proteomics 2010, 9, (6), 1085-99.(IF: 7.3)
  29. Zhang, H.; Guo, T.; Li, X.; Datta, A.; Park, J. E.; Yang, J.; Lim, S. K.; Tam, J. P.; Sze, S. K., Simultaneous characterization of glyco- and phosphoproteomes of mouse brain membrane proteome with electrostatic repulsion hydrophilic interaction chromatography. Mol Cell Proteomics 2010, 9, (4), 635-47.(IF: 7.3)
  30. Zhu, Y.; Guo, T.; Park, J. E.; Li, X.; Meng, W.; Datta, A.; Bern, M.; Lim, S. K.; Sze, S. K., Elucidating in vivo structural dynamics in integral membrane protein by hydroxyl radical footprinting. Mol Cell Proteomics 2009, 8, (8), 1999-2010.(IF: 7.3)