Bhushan, Shashi

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Selected Publications

  1. Singh D, Sielaff H, Sundararaman L, Bhushan S, Grüber G. The stimulating role of subunit F in ATPase activity inside the A1-complex of the Methanosarcina mazei Gö1 A1AO ATP synthase. Biochim Biophys Acta. 1857(2):177-87, 2016
  2. Candace YCT, Lapina MC, Bhushan S and Mueller-Cajar O. Identification and characterization of multiple Rubisco activases in chemoautotrophic bacteria. Nature Communications, 16;6:88832015, 2015
  3. Kumara V, Chen Y, Ero R, Ahmed T, Tan J, Li Z, Andrew See, Wong ASW, Bhushan S and Gao YG. The structure of BipA in GTP form bound to the ratcheted ribosome. PNAS 112: 10944-10949, 2015. Joint corresponding author
  4. Singh R, Kraft C, Jaiswal R, Sejwal K, Kasaragod VB, Kuper J, Bërger J, Mielke T, Luirink J, Bhushan S. Cryo-Electron Microscopic Structure of SecA Bound to the 70S Ribosome. J Biol Chem 289: 7190-7199, 2014
  5. Saha A, Chakraborty I, Kraft C, Bhushan S and Ghosh S. Microtubule nucleation from a functionalised SiO2 EM grid. RSC Adv 3: 7688–7691, 2013
  6. Winzer A, Kraft C, Bhushan S, Stepanenko V and Tessmer I. Correcting for AFM tip induced topography convolutions in protein-DNA samples. Ultramicroscopy 121: 08-15, 2012
  7. Bhushan S, Hoffman T, Seidelt B, Frauenfeld J, Mielke T, Berninghausen O, Wilson DN and Beckmann R. SecM-Stalled Ribosomes Adopt an Altered Geometry at the Peptidyl Transferase Center. PLOS Biology 9:e1000581, 2011
  8. Armache JP, Jarasch A, Anger AM, Villa E, Becker T, Bhushan S. et al., Localization of eukaryote-specific ribosomal proteins: Implications for structure, function and evolution. PNAS 107: 19754-59, 2010
  9. Armache JP, Jarasch A, Anger AM,  Villa E, Becker T, Bhushan S. et al., Cryo-EM structure of a translating eukaryotic 80S ribosome at 5.5 Å resolution. PNAS 107:19748-53, 2010
  10. Bhushan S, Mayer H, Starosta AL, Becker T, Mielke T, Berninghausen O, Sattler M, Wilson DN and Beckmann R. Structural basis of Arginine Attenuator Peptide and Cytomegalovirus mediated eukaryotic stalling, Mol Cell 40:138-46, 2010
  11. Bhushan S, Gartmann M, Halic M, Armache JP, Jarasch A, Mielke T,Berninghausen O, Wilson DN and Beckmann R. Alpha-helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel. Nat. Struct. Mol. Biol. 17:313-7, 2010
  12. Becker T, Bhushan S, Jarasch A, Armache JP, Funes S, Jossinet F, Gumbart J, Mielke T, Berninghausen O, Schulten K, Westhof E, Gilmore R, Mandon EC, Beckmann R. Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome. Science 326:1369-73, 2009.
  13. Pavlov PF, Rudhe C, Bhushan S and Glaser E. In vitro and in vivo protein import into plant mitochondria. Methods Mol Biol. 372:297-314, 2007
  14. Bhushan S, Pavlov PF, Rudhe C and Glaser E. In vitro and in vivo methods to study protein import into plant mitochondria. Methods Mol Biol. 390:131-50, 2007
  15. Glaser E, Nilsson S, Bhushan S. Two novel mitochondrial and chloroplastic targeting-peptide-degrading peptidasomes in A. thaliana, AtPreP1 and AtPreP2. Biol Chem. 387:1441-7, 2006
  16. Bhushan S, Johnson KA, Eneqvist T and Glaser E. Proteolytic mechanism of a novel mitochondrial and chloroplastic PreP peptidasome. Biol Chem. 387:1087-90, 2006
  17. Falkevall A, Alikhani N, Bhushan S, Pavlov PF, Busch K, Johnson KA, Eneqvist T, Tjernberg L, Ankarcrona M and Glaser E. Degradation of the amyloid betaprotein by the novel mitochondrial peptidasome, PreP. J Biol Chem. 281:29096-104, 2006
  18. Bhushan S, Kuhn C, Berglund AK, Roth C and Glaser E. The role of the N-terminal domain of chloroplast targeting peptides in organellar protein import and miss-sorting. FEBS Lett. 580:3966-72, 2006
  19. Johnson KA*, Bhushan S*, Ståhl A, Hallberg BM, Frohn A, Glaser E and Eneqvist T. The closed structure of presequence protease PreP forms a unique 10,000 Angstroms3 chamber for proteolysis. EMBO J. 25:1977-86, 2006
  20. P, Masiero S, Eubel H, Braun HP, Bhushan S, Glaser E, Salamini F and Leister D. Nuclear photosynthetic gene expression is synergistically modulated by rates of protein synthesis in chloroplasts and mitochondria. Plant Cell 18:970-91, 2006
  21. Ståhl A, Nilsson S, Lundberg P, Bhushan S, Biverståhl H, Moberg P, Morisset M, Vener A, Mäler L, Langel U and Glaser E . Two novel targeting peptide degrading proteases, PrePs, in mitochondria and chloroplasts, so similar and still different. J Mol Biol. 349:847-60, 2005
  22. Bhushan S, Ståhl A, Nilsson S, Lefebvre B, Seki M, Roth C, McWilliam D, Wright SJ, Liberles DA, Shinozaki K, Bruce BD, Boutry M and Glaser E. Catalysis, subcellular localization, expression and evolution of the targeting peptides degrading protease, AtPreP2. Plant Cell Physiol. 46:985-96, 2005
  23. Jain M, Tyagi Bhushan S, Thakur JK, Tyagi AK and Khurana JP. Molecular characterization of a light-responsive gene, breast basic conserved protein 1 (OsiBBC1), encoding nuclear-localized protein homologous to ribosomal protein L13 from Oryza sativa indica. Biochim Biophys Acta 20;1676(2):182-92, 2004
  24. Moberg P, Ståhl A, Bhushan S, Wright SJ, Eriksson A, Bruce BD and Glaser E. Characterization of a novel zinc metalloprotease involved in degrading targeting peptides in mitochondria and chloroplasts. Plant J. 36:616-28, 2003
  25. Bhushan S, Lefebvre B, Ståhl A, Wright SJ, Bruce BD, Boutry M and Glaser E. Dual targeting and function of a protease in mitochondria and chloroplasts. EMBO Rep. 4:1073-8, 2003