Preiser, Peter Rainer
Chair, School of Biological Sciences
Telephone: 6316 2869
- BA, Uni. of Delaware, 1986
- Ph.D., Uni. of Delaware, 1991
- Postdoctoral Fellow, Worcester Foundation for Experimental Biology, USA
- Postdoctoral Fellow, National Institute for Medical Research, London, UK
- Senior Research Scientist/Principal Investigator, National Institute for Medical Research, London, UK
- Associate Professor, School of Biological Sciences, Nanyang Technological University, Singapore.
My research interests focus on the molecular mechanisms by which the malaria parasite is able to avoid host immunity and adapt to changes in the host cell environment. One of the main problems in developing an efficient malaria vaccine is the ability of the parasite to evade host immune responses. Immune evasion happens both at the level of the infected red blood cell and at the process of invasion, the step at which the parasite infects a new cell. A number of multigene families have been recently identified within the genome of the parasite. It is believed that variation of the expression pattern of these genes are at least in part responsible for the adaptability of the parasite. Ongoing research efforts in the lab have focused on three different multigene families. One codes for a 235 kDa rhoptry protein and plays a crucial role in invasion, the second codes for the variant STEVOR antigen in Plasmodium falciparum and is located within the infected red blood cell while the third is related to the VIR multigene family of the human parasite Plasmodium vivax. In addition the lab also is interested in identifying potential drug targets that are involved in the DNA replication of the plastid DNA of P. falciparum.