Li Yinghui


Selected Publications

  1. Xu XY*, Li Y*, Ozturk MB, Tergaonkar V and Song HW. Structural basis and hetero-tetramerization requirement for activation of mutant TERT promoter by p52 and ETS1/2. Manuscript under revision. (*Co-first author)

  2. Ozturk MB, Li Y and Tergaonkar, V. (2017). Current insights to regulation and role of telomerase in human diseases. Antioxidants 2017 Feb 28;6(1).

  3. Li Y*, Cheng HS, Chng WJ and Tergaonkar V.* (2016) Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas. Proc. Natl. Acad. Sci. USA, Accepted manuscript. (*Co-corresponding author)

  4. Li Y* and Tergaonkar, V. (2016) Telomerase reactivation in cancers: Mechanisms that govern transcriptional activation of the wild-type vs. mutant TERT promoters. Transcription 7, 44-49. (*Corresponding author)

  5. Li Y, Zhou Q-L, Sun W, Chandrasekharan P, Cheng HS, Ying Z, Lakshmanan M, Raju A, Tenen DG, Cheng SY, Chuang KH, Li J, Prabhakar S, Li M, and Tergaonkar V. (2015). Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation. Nature Cell Biology 17, 1327-38.  *Highlighted in cover of October 2015 issue; featured in Cancer Discovery, Research Watch Nov 2015.

  6. Yang BX, El Farran CA, Guo HC, Yu T, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, and Loh YH. (2015). Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. Cell 163, 230-45.

  7. Koh CM, Khattar E, Leow SC, Liu CY, Muller J, Ang WX, Li Y, Franzoso G, Li S, Guccione E, and Tergaonkar V. (2015). Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. Journal of Clinical Investigation 125, 2109-22.

  8. Li, Y. and Tergaonkar, V. (2014). Noncanonical functions of telomerase: Implications in telomerase-targeted cancer therapies. Cancer Research 74, 1639-44.

  9. Kundu, P., Teo, W. L., Korecka, A., Li, Y., D’Arienzo, R., Bunte, R.M., Berger, T., Arulampalam, V., Chambon, P., Mak, T.W., Wahli, W. and Pettersson, S. (2014). Absence of Intestinal PPARγ Aggravates Acute Infectious Colitis in Mice through a Lipocalin-2-dependent Pathway. Plos Pathogens 10, e1003887.

  10. Li, Y., Teo, W.L., Low, M.J., Meijer, L., Sanderson, I., Pettersson, S., and Greicius, G. (2014). Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APCMin/+ mice. Oncogene 33, 369-77.

  11. Li, Y., Kundu, P., Seow, S.W., de Matos, C.T., Aronsson, L., Chin, K.C., Kärre, K., Pettersson, S., and Greicius, G. (2012). Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice. Carcinogenesis 33, 1231-1238.

  12. Zhang, W., Prakash, C., Sum, C., Gong, Y., Li, Y., Kwok, J.J.T., Thiessen, N., Pettersson, S., Jones, S.J.M., Knapp, S., Yang, H. and Chin, K.C. (2012). Bromodomain-containing Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells. Journal of Biological Chemistry 287, 43137-43155.

  13. Li Y, Du H, Bay BH and Olivo M. (2007). St John’s Wort: A Precious Gift from the Saints? Natural Products. Book chapter.

  14. Du H, Li Y, Olivo M, Yip GW and Bay BH. (2006). Differential up-regulation of metallothionein isoforms in well-differentiated nasopharyngeal cancer cells in vitro by photoactivated hypericin. Oncology Reports 16, 1397-1402.