Tam, James

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Publications (Journals)

1. Koncewicz, M., Mathinpatanam, P., Uchytil, T. F., Sparapano, L., Tam, J., Rich, D. H., and Durbin, R. D. (1973) Sequence and optical configuration of the amino acids xentoxin. Biochem Bioph Res Co 53: 653-8. IF: 2.371

2. Rich, D. H., Tam, J., Mathiaparanam, P., Grant, J. A., and Mabuni, C. (1974) General synthesis of didehydroamino-acids and peptides. J Chem Soc, Chem Commun: 897-898.

3. Rich, D. H., Tam, J., Mathiaparanam, P., and Grant, J. (1975) Selective N-Methylation of Dehydroamino Acid and Peptides. Synthesis-Stuttgart: 402-404. IF: 2.652

4. Rich, D. H., and Tam, J. P. (1975) Synthesis of Didehydropeptides from Peptides Containing 3-Alkylthio-Amino Acid Residues. Tetrahedron Lett: 211-212. IF: 2.347

5. Rich, D. H., and Tam, J. P. (1977) Method for Introducing Secondary Amide Bonds into Strained Cyclic Peptides. Tetrahedron Lett: 749-750. IF: 2.347

6. Rich, D. H., and Tam, J. P. (1977) Synthesis of Dehydro Amino-Acids and Peptides by Dehydrosulfenylation - Rate Enhancement Using Sulfenic Acid Trapping Agents. J Org Chem 42: 3815-3820. iF: 4.785

7. Tam, J. P., Cunninghamrundles, W. F., Erickson, B. W., and Merrifield, R. B. (1977) Selective Cleavage of Protected Amino-Acids and Peptides from Oxyacyl Resins by an 18-Crown-6 Complex of Potassium Cyanide. Tetrahedron Lett: 4001-4004. IF: 2.347

8. Rich, D. H., Bhatnagar, P., Mathiaparanam, P., Grant, J. A., and Tam, J. P. (1978) Synthesis of Tentoxin and Related Dehydro Cyclic Tetrapeptides. J Org Chem 43: 296-302. IF: 4.785

9. Rich, D. H., and Tam, J. P. (1978) Convenient Synthesis of Amino-Acid, 1-Aminocyclopropane-1-Carboxylic Acid. Synthesis-Stuttgart: 46-46. IF: 2.652

10. Tam, J. P., Kent, S. B. H., Wong, T. W., and Merrifield, R. B. (1979) Improved Synthesis of 4-(Boc-Aminoacyloxymethyl)-Phenylacetic Acids for Use in Solid-Phase Peptide-Synthesis. Synthesis-Stuttgart: 955-957. IF: 2.652

11. Tam, J. P., Tjoeng, F. S., and Merrifield, R. B. (1979) Multi-Detachable Resin Supports for Solid-Phase Fragment Synthesis. Tetrahedron Lett: 4935-4938. IF: 2.347

12. Tam, J. P., Wong, T. W., Riemen, M. W., Tjoeng, F. S., and Merrifield, R. B. (1979) Cyclohexyl Ester as a New Protecting Group for Aspartyl Peptides to Minimize Aspartimide Formation in Acidic and Basic Treatments. Abstr Pap Am Chem S: 123-123.

13. Tam, J. P., Wong, T. W., Riemen, M. W., Tjoeng, F. S., and Merrifield, R. B. (1979) Cyclohexyl Ester as a New Protecting Group for Aspartyl Peptides to Minimize Aspartimide Formation in Acidic and Basic Treatments. Tetrahedron Lett: 4033-4036. IF: 2.347

14. Tjoeng, F. S., Tam, J. P., and Merrifield, R. B. (1979) Solid-Phase Synthesis of the Protected 27-42 Hexadecapeptide of the Heavy-Chain from Myeloma Immunoglobulin M603 - Elimination of Side Reactions Associated with Glycyl-2-Oxypropionyl-Resin. Int J Pept Prot Res 14: 262-274. IF: 0.905

15. Tam, J. P., Dimarchi, R. D., and Merrifield, R. B. (1980) Photolabile Multi-Detachable Para-Alkoxybenzyl Alcohol Resin Supports for Peptide Fragment or Semi-Synthesis. Int J Pept Prot Res 16: 412-425. IF: 0.905

16. Tam, J. P., Tjoeng, F. S., and Merrifield, R. B. (1980) Design and synthesis of multidetachable resin supports for solid-phase peptide synthesis. J Am Chem Soc 102: 6117-6127. IF: 13.038

17. Lu, G., Mojsov, S., Tam, J. P., and Merrifield, R. B. (1981) Improved Synthesis of 4-Alkoxybenzyl Alcohol Resin. J Org Chem 46: 3433-3436. IF: 4.785

18. Sarin, V. K., Kent, S. B. H., Tam, J. P., and Merrifield, R. B. (1981) Quantitative Monitoring of Solid-Phase Peptide-Synthesis by the Ninhydrin Reaction. Anal Biochem 117: 147-157. IF: 2.243

19. Tam, J. P., Dimarchi, R. D., and Merrifield, R. B. (1981) Design and Synthesis of a Multi-Detachable Benzhydrylamine-Resin for Solid-Phase Peptide-Synthesis. Tetrahedron Lett 22: 2851-2854. IF: 2.347

20. Wang, S. S., Tam, J. P., Wang, B. S. H., and Merrifield, R. B. (1981) Enhancement of Peptide Coupling Reactions by 4-Dimethylaminopyridine. Int J Pept Prot Res 18: 459-467. IF: 0.905

21. Dimarchi, R. D., Tam, J. P., Kent, S. B. H., and Merrifield, R. B. (1982) Weak Acid-Catalyzed Pyrrolidone Carboxylic-Acid Formation from Glutamine during Solid-Phase Peptide-Synthesis - Minimization by Rapid Coupling. Int J Pept Prot Res 19: 88-93. IF: 0.905

22. Dimarchi, R. D., Tam, J. P., and Merrifield, R. B. (1982) Solid-Phase Synthesis of the Protected 43-55 Tridecapeptide of the Heavy-Chain of Myeloma Immunoglobin M603, Employing Cyclohexyl Ester Protection for Glutamic-Acid. Int J Pept Prot Res 19: 270-279. IF: 0.905

23. Heath, W. F., Tam, J. P., and Merrifield, R. B. (1982) Improved Deprotection in Solid-Phase Peptide-Synthesis - Deprotection of Ni-Formyl-Tryptophan to Tryptophan in Low Concentrations of Hf in Me2s-P-Thiocresol Mixtures. J Chem Soc Chem Comm: 896-897.

24. Tam, J. P., Heath, W. F., and Merrifield, R. B. (1982) Improved Deprotection in Solid-Phase Peptide-Synthesis - Quantitative Reduction of Methionine Sulfoxide to Methionine during Hf Cleavage. Tetrahedron Lett 23: 2939-2942. IF: 2.347

25. Tam, J. P., Heath, W. F., and Merrifield, R. B. (1982) Improved Deprotection in Solid-Phase Peptide-Synthesis - Removal of Protecting Groups from Synthetic Peptides by an Sn2 Mechanism with Low Concentrations of Hf in Dimethylsulfide. Tetrahedron Lett 23: 4435-4438. IF: 2.347

26. Tam, J. P. H. X. T. B. (1982) Multidetachable Resin Supports. Chemistry, Chinese Chemical Society 1-6. (not listed in web of science)

27. Tam, J. P., Heath, W. F., and Merrifield, R. B. (1983) Sn1 and Sn2 Mechanisms for the Deprotection of Synthetic Peptides by Hydrogen-Fluoride - Studies to Minimize the Tyrosine Alkylation Side Reaction. Int J Pept Prot Res 21: 57-65. IF: 0.905

28. Tam, J. P., Heath, W. F., and Merrifield, R. B. (1983) Sn2 Deprotection of Synthetic Peptides with a Low Concentration of Hf in Dimethyl Sulfide - Evidence and Application in Peptide-Synthesis. J Am Chem Soc 105: 6442-6455. IF: 13.038

29. Voss, C., Dimarchi, R., Whitney, D. B., Tjoeng, F. S., Merrifield, R. B., and Tam, J. P. (1983) Synthesis of the Protected Tridecapeptide (56-68) of the Vh Domain of Mouse Myeloma Immunoglobulin M603 and Its Reattachment to Resin Supports. Int J Pept Prot Res 22: 204-213. IF: 0.905

30. Tam, J. P., Marquardt, H., Rosberger, D. F., Wong, T. W., and Todaro, G. J. (1984) Synthesis of biologically active rat transforming growth factor I. Nature 309: 376-378. IF: 38.138

31. Whitney, D. B., Tam, J. P., and Merrifield, R. B. (1984) A New Base-Catalyzed Cleavage Reaction for the Preparation of Protected Peptides. Tetrahedron 40: 4237-4244. IF: 2.645

32. Arnot, D. E., Barnwell, J. W., Tam, J. P., Nussenzweig, V., Nussenzweig, R. S., and Enea, V. (1985) Circumsporozoite Protein of Plasmodium-Vivax - Gene Cloning and Characterization of the Immunodominant Epitope. Science 230: 815-818. IF: 34.661

33. Feldman, R. A., Gabrilove, J. L., Tam, J. P., Moore, M. A. S., and Hanafusa, H. (1985) Specific Expression of the Human Cellular Fps Fes-Encoded Protein Ncp92 in Normal and Leukemic Myeloid Cells. P Natl Acad Sci USA 82: 2379-2383. IF: 9.423

34. Nakhla, A. M., and Tam, J. P. (1985) Transforming Growth-Factor Is a Potent Stimulator of Testicular Ornithine Decarboxylase in Immature Mouse. Biochem Bioph Res Co 132: 1180-1186. IF: 2.371

35. Tam, J. P. (1985) A Gradative Deprotection Strategy for the Solid-Phase Synthesis of Peptide Amides Using Para-(Acyloxy)Benzhydrylamine Resin and the Sn2 Deprotection Method. J Org Chem 50: 5291-5298. IF: 4.785

36. Tam, J. P. (1985) Physiological-Effects of Transforming Growth-Factor in the Newborn Mouse. Science 229: 673-675. IF: 34.661

37. Tam, J. P., and Merrifield, R. B. (1985) Solid-Phase Synthesis of Gastrin-I - Comparison of Methods Utilizing Strong Acid for Deprotection and Cleavage. Int J Pept Prot Res 26: 262-273. IF: 0.905

38. Zavala, F., Tam, J. P., Hollingdale, M. R., Cochrane, A. H., Quakyi, I., Nussenzweig, R. S., and Nussenzweig, V. (1985) Rationale for Development of a Synthetic Vaccine against Plasmodium-Falciparum Malaria. Science 228: 1436-1440. IF: 34.661

39. Aley, S. B., Bates, M. D., Tam, J. P., and Hollingdale, M. R. (1986) Synthetic Peptides from the Circumsporozoite Proteins of Plasmodium-Falciparum and Plasmodium-Knowlesi Recognize the Human Hepatoma-Cell Line Hepg2-A16 Invitro. J Exp Med 164: 1915-1922. IF: 11.24

40. Eichinger, D. J., Arnot, D. E., Tam, J. P., Nussenzweig, V., and Enea, V. (1986) Circumsporozoite Protein of Plasmodium-Gerghei - Gene Cloning and Identification of the Immunodominant Epitopes. Mol Cell Biol 6: 3965-3972. IF: 4.427

41. Feldman, R. A., Tam, J. P., and Hanafusa, H. (1986) Antipeptide antiserum identifies a widely distributed cellular tyrosine kinase related to but distinct from the c-fps/fes-encoded protein. Mol Cell Biol 6: 1065-73. IF: 4.427

42. Heath, W. F., Tam, J. P., and Merrifield, R. B. (1986) Improved Deprotection of Cysteine-Containing Peptides in Hf. Int J Pept Prot Res 28: 498-507. IF: 0.905

43. Perroteau, I., Salomon, D., Debortoli, M., Kidwell, W., Hazarika, P., Pardue, R., Dedman, J., and Tam, J. (1986) Immunological Detection and Quantitation of Alpha-Transforming Growth-Factors in Human-Breast Carcinoma-Cells. Breast Cancer Res Tr 7: 201-210. IF: 4.085

44. Rhodes, J. A., Tam, J. P., Finke, U., Saunders, M., Bernanke, J., Silen, W., and Murphy, R. A. (1986) Transforming Growth-Factor Alpha-Inhibits Secretion of Gastric-Acid. P Natl Acad Sci USA 83: 3844-3846. IF: 9.423

45. Tam, J. P., Heath, W. F., and Merrifield, R. B. (1986) Mechanisms for the Removal of Benzyl Protecting Groups in Synthetic Peptides by Trifluoromethanesulfonic Acid Trifluoroacetic-Acid Dimethyl Sulfide. J Am Chem Soc 108: 5242-5251. IF: 13.038

46. Tam, J. P., Sheikh, M., Harris, P., Pileggi, N., Tsai, L., and Hampton, R. (1986) Alpha-transforming growth factor: biological activity and structure-activity relationships. Proc West Pharmacol Soc 29: 471-4. (not listed in web of science)

47. Tam, J. P., Sheikh, M. A., Solomon, D. S., and Ossowski, L. (1986) Efficient Synthesis of Human Type Alpha-Transforming Growth-Factor - Its Physical and Biological Characterization. P Natl Acad Sci USA 83: 8082-8086. IF: 9.423

48. Zavala, F., Tam, J. P., and Masuda, A. (1986) Synthetic Peptides as Antigens for the Detection of Humoral Immunity to Plasmodium-Falciparum Sporozoites. J Immunol Methods 93: 55-61. IF: 1.858

49. Salomon, D. S., Perroteau, I., Kidwell, W. R., Tam, J., and Derynck, R. (1987) Loss of Growth Responsiveness to Epidermal Growth-Factor and Enhanced Production of Alpha-Transforming Growth-Factors in Ras-Transformed Mouse Mammary Epithelial-Cells. J Cell Physiol 130: 397-409. IF: 4.155

50. Tam, J. P. (1987) Solid-Phase Synthesis of Type-Alpha Transforming Growth-Factor. Method Enzymol 146: 127-143. IF: 2.088

51. Tam, J. P. (1987) Synthesis of Biologically-Active Transforming Growth Factor-Alpha. Int J Pept Prot Res 29: 421-431. IF: 0.905

52. Yeh, Y. C., Tsai, J. F., Chuang, L. Y., Yeh, H. W., Tsai, J. H., Florine, D. L., and Tam, J. P. (1987) Elevation of Transforming Growth Factor-Alpha and Its Relationship to the Epidermal Growth-Factor and Alpha-Fetoprotein Levels in Patients with Hepatocellular-Carcinoma. Cancer Res 47: 896-901. IF: 8.556

53. Zavala, F., Tam, J. P., Barr, P. J., Romero, P. J., Ley, V., Nussenzweig, R. S., and Nussenzweig, V. (1987) Synthetic Peptide Vaccine Confers Protection against Murine Malaria. J Exp Med 166: 1591-1596. IF: 11.24

54. Bates, S. E., Davidson, N. E., Valverius, E. M., Freter, C. E., Dickson, R. B., Tam, J. P., Kudlow, J. E., Lippman, M. E., and Salomon, D. S. (1988) Expression of Transforming Growth Factor-Alpha and Its Messenger Ribonucleic-Acid in Human-Breast Cancer - Its Regulation by Estrogen and Its Possible Functional-Significance. Mol Endocrinol 2: 543-555. IF: 3.432

55. Chang, K. J., Pugh, W., Blanchard, S. G., Mcdermed, J., and Tam, J. P. (1988) Antibody Specific to the Alpha-Subunit of the Guanine Nucleotide-Binding Regulatory Protein-G - Developmental Appearance and Immunocytochemical Localization in Brain. P Natl Acad Sci USA 85: 4929-4933. IF: 9.423

56. Gottlieb, A. B., Chang, C. K., Posnett, D. N., Fanelli, B., and Tam, J. P. (1988) Detection of Transforming Growth Factor-Alpha in Normal, Malignant, and Hyperproliferative Human Keratinocytes. J Exp Med 167: 670-675. IF: 11.24

57. Kaiser Sr, E., Tam, J. P., Kubiak, T. M., and Merrifield, R. B. (1988) Chlorotrimethylsilane-phenol as a mild deprotection reagent for the tert-butyl based protecting groups in peptide synthesis. Tetrahedron Lett 29: 303-306. IF: 2.645

58. Lin, Y. Z., Caporaso, G., Chang, P. Y., Ke, X. H., and Tam, J. P. (1988) Synthesis of a Biological Active-Tumor Growth-Factor from the Predicted DNA-Sequence of Shope Fibroma Virus. Biochemistry 27: 5640-5645. IF: 2.876

59. Posnett, D. N., Mcgrath, H., and Tam, J. P. (1988) A Novel Method for Producing Anti-Peptide Antibodies - Production of Site-Specific Antibodies to the T-Cell Antigen Receptor Beta-Chain. J Biol Chem 263: 1719-1725. IF: 4.258

60. Romero, P. J., Tam, J. P., Schlesinger, D., Clavijo, P., Gibson, H., Barr, P. J., Nussenzweig, R. S., Nussenzweig, V., and Zavala, F. (1988) Multiple T-Helper Cell Epitopes of the Circumsporozoite Protein of Plasmodium-Berghei. Eur J Immunol 18: 1951-1957. IF: 4.179

61. Tam, J. P. (1988) Synthetic Peptide Vaccine Design - Synthesis and Properties of a High-Density Multiple Antigenic Peptide System. P Natl Acad Sci USA 85: 5409-5413. IF: 9.423

62. Tam, J. P., Riemen, M. W., and Merrifield, R. B. (1988) Mechanisms of aspartimide formation: the effects of protecting groups, acid, base, temperature and time. Peptide Res 1: 6-18. (not listed in web of science)

63. Ye, Y. K., Lin, Y. Z., and Tam, J. P. (1988) Shope Fibroma Virus Growth-Factor Exhibits Epidermal Growth-Factor Activities in Newborn Mice. Biochem Bioph Res Co 154: 497-501. IF: 2.371

64. Berg, R. H., Almdal, K., Pedersen, W. B., Holm, A., Tam, J. P., and Merrifield, R. B. (1989) Long-Chain Polystyrene-Grafted Polyethylene Film Matrix - a New Support for Solid-Phase Peptide-Synthesis. J Am Chem Soc 111: 8024-8026. IF: 13.038

65. Hoeprich, P. D., Langton, B. C., Zhang, J. W., and Tam, J. P. (1989) Identification of Immunodominant Regions of Transforming Growth Factor-Alpha - Implications of Structure and Function. J Biol Chem 264: 19086-19091. IF: 4.258

66. Huang, L. H., Ke, X. H., Sweeney, W., and Tam, J. P. (1989) Calcium-Binding and Putative Activity of the Epidermal Growth-Factor Domain of Blood-Coagulation Factor-Ix. Biochem Bioph Res Co 160: 133-139. IF: 2.371

67. Posnett, D. N., and Tam, J. P. (1989) Multiple Antigenic Peptide Method for Producing Antipeptide Site-Specific Antibodies. Method Enzymol 178: 739-746. IF: 2.088

68. Ryan, J., Wolitzky, B., Heimer, E., Lambrose, T., Felix, A., Tam, J. P., Huang, L. H., Nawroth, P., Wilner, G., Kisiel, W., Nelsestuen, G. L., and Stern, D. M. (1989) Structural Determinants of the Factor-Ix Molecule Mediating Interaction with the Endothelial-Cell Binding-Site Are Distinct from Those Involved in Phospholipid Binding. J Biol Chem. 264: 20283-20287. IF: 4.258

69. Stenflo, J., Holme, E., Lindstedt, S., Chandramouli, N., Huang, L. H. T., Tam, J. P., and Merrifield, R. B. (1989) Hydroxylation of Aspartic-Acid in Domains Homologous to the Epidermal Growth-Factor Precursor Is Catalyzed by a 2-Oxoglutarate-Dependent Dioxygenase. P Natl Acad Sci USA 86: 444-447. IF: 9.423

70. Tam, J. P. (1989) High-Density Multiple Antigen Peptide System for Preparation of Antipeptide Antibodies. Method Enzymol 168: 7-15. IF: 2.088

71. Tam, J. P., and Lu, Y. A. (1989) Vaccine Engineering - Enhancement of Immunogenicity of Synthetic Peptide Vaccines Related to Hepatitis in Chemically Defined Models Consisting of T-Cell and B-Cell Epitopes. P Natl Acad Sci USA 86: 9084-9088. IF: 9.423

72. Tam, J. P., and Zavala, F. (1989) Multiple antigen peptide. A novel approach to increase detection sensitivity of synthetic peptides in solid-phase immunoassays. J Immunol Methods 124: 53-61. IF: 1.858

73. Vergara, U., and Tam, J. P. (1989) A novel design of peptide immunogens: synthetic peptide with a reversible handle for the attachment to protein carriers. Peptide Res 2: 134-9. (not listed in web of science)

74. Chang, W., Macaulay, C., Hu, S. L., Tam, J. P., and McFadden, G. (1990) Tumorigenic poxviruses: characterization of the expression of an epidermal growth factor related gene in Shope fibroma virus. Virology 179: 926-30. IF: 3.2

75. Lin, Y. Z., Isaac, D. D., and Tam, J. P. (1990) Synthesis and Properties of Cholecystokinin-Releasing Peptide (Monitor Peptide), a 61-Residue Trypsin-Inhibitor. Int J Pept Prot Res 36: 433-439. IF: 0.905

76. Lin, Y. Z., Ke, X. H., and Tam, J. P. (1990) Growth-Inhibition by Vaccinia Virus Growth-Factor. J Biol Chem. 265: 18884-18890. IF: 4.258

77. Tam, J. P., Clavijo, P., Lu, Y. A., Nussenzweig, V., Nussenzweig, R., and Zavala, F. (1990) Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria. J Exp Med 171: 299-306. IF: 11.24

78. Fehlner, P. F., Berg, R. H., Tam, J. P., and King, T. P. (1991) Murine T-Cell Responses to Melittin and Its Analogs. J Immunol 146: 799-806. IF: 4.985

79. Francis, M. J., Hastings, G. Z., Brown, F., Mcdermed, J., Lu, Y. A., and Tam, J. P. (1991) Immunological Evaluation of the Multiple Antigen Peptide (Map) System Using the Major Immunogenic Site of Foot-and-Mouth-Disease Virus. Immunology 73: 249-254.  IF: 4.078

80. Huang, L. H., Cheng, H., Pardi, A., Tam, J. P., and Sweeney, W. V. (1991) Sequence-specific 1H NMR assignments, secondary structure, and location of the calcium binding site in the first epidermal growth factor like domain of blood coagulation factor IX. Biochemistry 30: 7402-9. IF: 2.876

81. Lin, Y. Z., Ke, X. H., and Tam, J. P. (1991) Synthesis and structure-activity study of myxoma virus growth factor. Biochemistry 30: 3310-4. IF: 2.876

82. Lu, Y. A., Clavijo, P., Galantino, M., Shen, Z. Y., Liu, W., and Tam, J. P. (1991) Chemically Unambiguous Peptide Immunogen - Preparation, Orientation and Antigenicity of Purified Peptide Conjugated to the Multiple Antigen Peptide System. Mol Immunol 28: 623-630. IF: 3.375

83. Tam, J. P., Lin, Y. Z., Liu, W., Wang, D. X., Ke, X. H., and Zhang, J. W. (1991) Mapping the receptor-recognition site of human transforming growth factor-alpha. Int J Pept Prot Res 38: 204-11. IF: 0.905

84. Tam, J. P., Wu, C. R., Liu, W., and Zhang, J. W. (1991) Disulfide Bond Formation in Peptides by Dimethyl-Sulfoxide - Scope and Applications. J Am Chem Soc 113: 6657-6662. IF: 13.038

85. Wang, C. Y., Looney, D. J., Li, M. L., Walfield, A. M., Ye, J., Hosein, B., Tam, J. P., and Wongstaal, F. (1991) Long-Term High-Titer Neutralizing Activity Induced by Octameric Synthetic Hiv-1 Antigen. Science 254: 285-288. IF: 34.661

86. Chai, S. K., Clavijo, P., Tam, J. P., and Zavala, F. (1992) Immunogenic properties of multiple antigen peptide systems containing defined T and B epitopes. J Immunol 149: 2385-90. IF: 4.985

87. Defoort, J. P., Nardelli, B., Huang, W., Ho, D. D., and Tam, J. P. (1992) Macromolecular assemblage in the design of a synthetic AIDS vaccine. P Natl Acad Sci USA 89: 3879-83. IF: 9.423

88. Defoort, J. P., Nardelli, B., Huang, W., and Tam, J. P. (1992) A Rational Design of Synthetic Peptide Vaccine with a Built-in Adjuvant - a Modular Approach for Unambiguity. Int J Pept Prot Res 40: 214-221. IF: 0.905

89. Estival, A., Clerc, P., Vaysse, N., Tam, J. P., and Clemente, F. (1992) Decreased expression of transforming growth factor alpha during differentiation of human pancreatic cancer cells. Gastroenterology 103: 1851-9. IF: 18.187

90. Nardelli, B., Defoort, J. P., Huang, W. L., and Tam, J. P. (1992) Design of a Complete Synthetic Peptide-Based Aids Vaccine with a Built-in Adjuvant. Aids Res Hum Retrov 8: 1405-1407.

91. Nardelli, B., Lu, Y. A., Shiu, D. R., Delpierredefoort, C., Profy, A. T., and Tam, J. P. (1992) A Chemically Defined Synthetic Vaccine Model for Hiv-1. J Immunol 148: 914-920. IF: 4.985

92. Nonacs, R., Humborg, C., Tam, J. P., and Steinman, R. M. (1992) Mechanisms of Mouse Spleen Dendritic Cell-Function in the Generation of Influenza-Specific, Cytolytic Lymphocytes-T. J Exp Med 176: 519-529. IF: 11.24

93. Tam, J. P., and Shen, Z. Y. (1992) Efficient approach to synthesis of two-chain asymmetric cysteine analogs of receptor-binding region of transforming growth factor-alpha. Int J Pept Prot Res 39: 464-71. IF: 0.905

94. Vanage, G., Lu, Y. A., Tam, J. P., and Koide, S. S. (1992) Infertility Induced in Rats by Immunization with Synthetic Peptide Segments of a Sperm Protein. Biochem Bioph Res Co 183: 538-543. IF: 2.371

95. Wang, S. S., Wang, B. S. H., Hughes, J. L., Leopold, E. J., Wu, C. R., and Tam, J. P. (1992) Cleavage and Deprotection of Peptides on Mbha-Resin with Hydrogen Bromide. Int J Pept Prot Res 40: 344-349. IF: 0.905

96. Yang, Y. Y., Johnson, T. M., Mecham, J. O., Tam, J. P., and Li, J. K. K. (1992) Epitopic Mapping of Linear and Conformation-Dependent Antigenic Determinants on Gp5 of 5 United-States Bluetongue Viruses. Virology 188: 530-536. IF: 3.2

97. Calvocalle, J. M., Deoliveira, G. A., Clavijo, P., Maracic, M., Tam, J. P., Lu, Y. A., Nardin, E. H., Nussenzweig, R. S., and Cochrane, A. H. (1993) Immunogenicity of Multiple Antigen Peptides Containing-B and Non-Repeat T-Cell Epitopes of the Circumsporozoite Protein of Plasmodium-Falciparum. J Immunol 150: 1403-1412. IF: 4.985

98. Kaiser, E., Picart, F., Kubiak, T., Tam, J. P., and Merrifield, R. B. (1993) Selective deprotection of the N.alpha.-tert-butyloxycarbonyl group in solid phase peptide synthesis with chlorotrimethylsilane in phenol. J Org Chem 58: 5167-5175. IF: 4.785

99. Nardelli, B., and Tam, J. P. (1993) Cellular Immune-Responses Induced by in-Vivo Priming with a Lipid-Conjugated Multimeric Antigen Peptide. Immunology 79: 355-361. IF: 4.078

100. Huang, W. L., Nardelli, B., and Tam, J. P. (1994) Lipophilic Multiple Antigen Peptide System for Peptide Immunogen and Synthetic Vaccine. Mol Immunol 31: 1191-1199. IF: 3.375

101. Liu, C. F., and Tam, J. P. (1994) Chemical Ligation Approach to Form a Peptide-Bond between Unprotected Peptide Segments - Concept and Model Study. J Am Chem Soc 116: 4149-4153. IF: 13.038

102. Liu, C. F., and Tam, J. P. (1994) Peptide Segment Ligation Strategy without Use of Protecting Groups. P Natl Acad Sci USA 91: 6584-6588. IF: 9.423

103. Nardelli, B., Haser, P. B., and Tam, J. P. (1994) Oral administration of an antigenic synthetic lipopeptide (MAP-P3C) evokes salivary antibodies and systemic humoral and cellular responses. Vaccine 12: 1335-9. IF: 3.413

104. Rao, C., and Tam, J. P. (1994) Synthesis of Peptide Dendrimer. J Am Chem Soc 116: 6975-6976. IF: 13.038

105. Spetzler, J. C., Rao, C., and Tam, J. P. (1994) A novel strategy for the synthesis of the cysteine-rich protective antigen of the malaria merozoite surface protein (MSP-1). Knowledge-based strategy for disulfide formation. Int J Pept Prot Res 43: 351-8.

106. Tam, J. P., Liu, W., Zhang, J. W., Galantino, M., Bertolero, F., Cristiani, C., Vaghi, F., and Decastiglione, R. (1994) Alanine Scan of Endothelin - Importance of Aromatic Residues. Peptides 15: 703-708. IF: 2.535

107. Vanage, G. R., Jaiswal, Y. K., Lu, Y. A., Tam, J. P., Wang, L. F., and Koide, S. S. (1994) Immunization with synthetic peptide segments of a sperm protein impair fertility in rats. Res Commun Chem Pathol Pharmacol 84: 3-15.

108. Yang, Y., Sweeney, W. V., Schneider, K., Chait, B. T., and Tam, J. P. (1994) Two-step selective formation of three disulfide bridges in the synthesis of the C-terminal epidermal growth factor-like domain in human blood coagulation factor IX. Protein science : a publication of the Protein Society 3: 1267-75. 

109. Yang, Y., Sweeney, W. V., Schneider, K., Thornqvist, S., Chait, B. T., and Tam, J. P. (1994) Aspartimide Formation in Base-Driven 9-Fluorenylmethoxycarbonyl Chemistry. Tetrahedron Lett 35: 9689-9692. IF: 2.645

110. Galantino, M., de Castiglione, R., Cristiani, C., Vaghi, F., Liu, W., Zhang, J. W., and Tam, J. P. (1995) D-amino acid scan of endothelin: importance of amino acids adjacent to cysteinyl residues in isomeric selectivity. Peptide Res 8: 154-9.

111. Nardelli, B., and Tam, J. P. (1995) The MAP system. A flexible and unambiguous vaccine design of branched peptides. Pharm Biotechnol 6: 803-19. (not listed in web of science) 

112. Pallin, T. D., and Tam, J. P. (1995) Cyclization of Totally Unprotected Peptides in Aqueous-Solution by Oxime Formation. J Chem Soc Chem Comm: 2021-2022.

113. Shao, J., and Tam, J. P. (1995) Unprotected Peptides as Building-Blocks for the Synthesis of Peptide Dendrimers with Oxime, Hydrazone, and Thiazolidine Linkages. J Am Chem Soc 117: 3893-3899. IF: 13.038

114. Tam, J. P., and Lu, Y. A. (1995) Coupling Difficulty Associated with Interchain Clustering and Phase-Transition in Solid-Phase Peptide-Synthesis. J Am Chem Soc 117: 12058-12063. IF: 13.038

115. Tam, J. P., Lu, Y. A., Liu, C. F., and Shao, J. (1995) Peptide synthesis using unprotected peptides through orthogonal coupling methods. P Natl Acad Sci USA 92: 12485-12489. IF: 9.423

116. Tam, J. P., Rao, C., Liu, C. F., and Shao, J. (1995) Specificity and Formation of Unusual Amino-Acids of an Amide Ligation Strategy for Unprotected Peptides. Int J Pept Prot Res 45: 209-216. 

117. Tam, J. P., and Spetzler, J. C. (1995) Chemoselective approaches to the preparation of peptide dendrimers and branched artificial proteins using unprotected peptides as building blocks. Biomed Pept Proteins Nucleic Acids 1: 123-32. (not listed in web of science)

118. Botti, P., Pallin, T. D., and Tam, J. P. (1996) Cyclic peptides from linear unprotected peptide precursors through thiazolidine formation. J Am Chem Soc 118: 10018-10024. IF: 13.038

119. Liu, C. F., Rao, C., and Tam, J. P. (1996) Acyl disulfide-mediated intramolecular acylation for orthogonal coupling between unprotected peptide segments. Mechanism and application. Tetrahedron Lett 37: 933-936. IF: 2.645

120. Liu, C. F., Rao, C., and Tam, J. P. (1996) Orthogonal ligation of unprotected peptide segments through pseudoproline formation for the synthesis of HIV-1 protease. J Am Chem Soc 118: 307-312. IF: 13.038

121. Pallin, T. D., and Tam, J. P. (1996) Assembly of cyclic peptide dendrimers from unprotected linear building blocks in aqueous solution. Chem Commun: 1345-1346. iF: 6.567

122. Spetzler, J. C., and Tam, J. P. (1996) Self-assembly of cyclic peptides on a dendrimer: Multiple cyclic antigen peptides. Peptide Res 9: 290-296.

123. Tam, J. P. (1996) Recent advances in multiple antigen peptides. J Immunol Methods 196: 17-32. IF: 1.858

124. Zhang, L. S., and Tam, J. P. (1996) Thiazolidine formation as a general and site-specific conjugation method for synthetic peptides and proteins. Anal Biochem 233: 87-93. IF: 2.243

125. Liu, C.-F., and Tam, J. P. (1997) Synthesis of a Symmetric Peptide Dendrimer.  Assembly of a Cyclic Peptide on a Small Tetraacetate Template. Chem. Comm., : 1619-1620. IF: 6.567

126. Tam, J. P., and Lu, Y. A. (1997) Synthesis of large cyclic cystine-knot peptide by orthogonal coupling strategy using unprotected peptide precursor. Tetrahedron Lett 38: 5599-5602. IF: 2.645

127. Zhang, L. S., and Tam, J. P. (1997) Synthesis and application of unprotected cyclic peptides as building blocks for peptide dendrimers. J Am Chem Soc 119: 2363-2370. IF: 13.038

128. Zhang, L. S., and Tam, J. P. (1997) Metal ion-assisted peptide cyclization. Tetrahedron Lett 38: 4375-4378. IF: 2.645

129. Zhang, L. S., and Tam, J. P. (1997) Orthogonal coupling of unprotected peptide segments through histidyl amino terminus. Tetrahedron Lett 38: 3-6. IF: 2.645

130. Kaljuste, K., and Tam, J. P. (1998) A novel on-resin synthesis of c-terminally amidated peptides. Tetrahedron Lett 39: 9327-9330. IF: 2.645

131. Mora, A. L., and Tam, J. P. (1998) Controlled lipidation and encapsulation of peptides as a useful approach to mucosal immunizations. J Immunol 161: 3616-3623. IF: 4.985

132. Tam, J. P., and Lu, Y. A. (1998) A biomimetic strategy in the synthesis and fragmentation of cyclic protein. Protein Sci 7: 1583-1592. IF: 3.039

133. Tam, J. P., and Yu, Q. T. (1998) Methionine ligation strategy in the biomimetic synthesis of parathyroid hormones. Biopolymers 46: 319-327. If: 2.248

134. Zhang, L. S., Torgerson, T. R., Liu, X. Y., Timmons, S., Colosia, A. D., Hawiger, J., and Tam, J. P. (1998) Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules. P Natl Acad Sci USA 95: 9184-9189. IF: 9.423

135. An, S. S. A., Lester, C. C., Peng, J. L., Li, Y. J., Rothwarf, D. M., Welker, E., Thannhauser, T. W., Zhang, L. S., Tam, J. P., and Scheraga, H. A. (1999) Retention of the cis proline conformation in tripeptide fragments of bovine pancreatic ribonuclease A containing a non-natural proline analogue, 5,5-dimethylproline. J Am Chem Soc 121: 11558-11566. IF: 13.038

136. Tam, J. P., Dong, X. C., and Wu, C. R. (1999) Solvent assistance in regiospecific disulfide formation in dimethylsulfoxide. Lett Pept Sci 6: 265-273.

137. Tam, J. P., Lu, Y. A., Yang, J. L., and Chiu, K. W. (1999) An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. P Natl Acad Sci USA 96: 8913-8918. IF: 9.423

138. Tam, J. P., Lu, Y. A., and Yu, Q. T. (1999) Thia zip reaction for synthesis of large cyclic peptides: Mechanisms and applications. J Am Chem Soc 121: 4316-4324. IF: 13.038

139. Tam, J. P., and Miao, Z. W. (1999) Stereospecific pseudoproline ligation of N-terminal serine, threonine, or cysteine-containing unprotected peptides. J Am Chem Soc 121: 9013-9022. IF: 13.038

140. Tam, J. P., Yu, Q. T., and Miao, Z. W. (1999) Orthogonal ligation strategies for peptide and protein. Biopolymers 51: 311-332.  IF: 2.248

141. Zhang, L. S., and Tam, J. P. (1999) Lactone and lactam library synthesis by silver ion-assisted orthogonal cyclization of unprotected peptides. J Am Chem Soc 121: 3311-3320.  IF: 13.038 

142. Chang, M., Zhang, L. S., Tam, J. P., and Sanders-Bush, E. (2000) Dissecting G protein-coupled receptor signaling pathways with membrane-permeable blocking peptides - Endogenous 5-HT2C receptors in choroid plexus epithelial cells. J Biol Chem. 275: 7021-7029. IF: 4.258

143. Li, X. F., Zhang, L. S., Hall, S. E., and Tam, J. P. (2000) A new ligation method for N-terminal tryptophan-containing peptides using the Pictet-Spengler reaction. Tetrahedron Lett 41: 4069-4073. IF: 2.645

144. Li, X. F., Zhang, L. S., Zhang, W., Hall, S. E., and Tam, J. P. (2000) Solid-phase synthesis of 1,2,3,4-tetrahydro-beta-carboline-containing peptidomimetics. Org Lett 2: 3075-3078. IF: 6.732

145. Miao, Z. W., and Tam, J. P. (2000) Dehydropeptides from orthogonal ligation of unprotected peptides. Org Lett 2: 3711-3713. IF: 6.732

146. Miao, Z. W., and Tam, J. P. (2000) Bidirectional tandem pseudoproline ligations of proline-rich helical peptides. J Am Chem Soc 122: 4253-4260. IF: 13.038

147. Tam, J. P., Lu, Y. A., and Yang, J. L. (2000) Design of salt-insensitive glycine-rich antimicrobial peptides with cyclic tricystine structures. Biochemistry 39: 7159-7169. IF: 2.876

148. Tam, J. P., Lu, Y. A., and Yang, J. L. (2000) Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Bioph Res Co 267: 783-790. IF: 2.371

149. Tam, J. P., Wu, C. W., and Yang, J. L. (2000) Membranolytic selectivity of cystine-stabilized cyclic protegrins. Eur J Biochem 267: 3289-3300. IF: 2.69

150. Yu, Q. T., Lehrer, R. I., and Tam, J. P. (2000) Engineered salt-insensitive alpha-defensins with end-to-end circularized structures. J Biol Chem 275: 3943-3949.  IF: 4.258

151. Liu, C. F., and Tam, J. P. (2001) Subtilisin-catalyzed synthesis of amino acid and peptide esters. Application in a two-step enzymatic ligation strategy. Org Lett 3: 4157-4159.  IF: 6.732

152. Muhle, S. A., and Tam, J. P. (2001) Design of gram-negative selective antimicrobial peptides. Biochemistry 40: 5777-5785. IF: 2.876

153. Sun, Y., Lu, G. S., and Tam, J. P. (2001) A thioester ligation approach to amphipathic bicyclic peptide library. Org Lett 3: 1681-1684. IF: 6.732

154. Tam, J. P., Xu, J. X., and Eom, K. D. (2001) Methods and strategies of peptide ligation. Biopolymers/Peptide Sc 60: 194-205. IF: 2.248

155. Tam, J. P., Yu, Q., and Lu, Y. A. (2001) Tandem peptide ligation for synthetic and natural biologicals. Biologicals 29: 189-196. IF: 1.69

156. Tam, J. P., Yu, Q. T., and Yang, J. L. (2001) Tandem ligation of unprotected peptides through thiaprolyl and cysteinyl bonds in water. J Am Chem Soc 123: 2487-2494.  IF: 13.038

157. Sadler, K., Eom, K. D., Yang, J. L., Dimitrova, Y., and Tam, J. P. (2002) Translocating proline-rich peptides from the antimicrobial peptide bactenecin 7. Biochemistry 41: 14150-14157. IF: 2.876

158. Sadler, K., and Tam, J. P. (2002) Peptide dendrimers: applications and synthesis. J Biotechnol 90: 195-229. (not listed in web of science)  IF: 2.667

159. Tam, J. P., Lu, Y. A., and Yang, J. L. (2002) Correlations of cationic charges with salt sensitivity and microbial specificity of cystine-stabilized beta-strand antimicrobial peptides. J Biol Chem 277: 50450-50456. IF: 4.258

160. Tam, J. P., Lu, Y. A., and Yang, J. L. (2002) Antimicrobial dendrimeric peptides. Eur J Biochem 269: 923-932. IF: 2.69

161. Tam, J. P., and Yu, Q. T. (2002) A facile ligation approach to prepare three-helix bundles of HIV fusion-state protein mimetics. Org Lett 4: 4167-4170.  IF: 6.732

162. Eom, K. D., Miao, Z. W., Yang, J. L., and Tam, J. P. (2003) Tandem ligation of multipartite peptides with cell-permeable activity. J Am Chem Soc 125: 73-82. IF: 13.038

163. Liao, Y., Lescar, J., Tam, J. P., and Liu, D. X. (2004) Expression of SARS-coronavirus envelope protein in Escherichia coli cells alters membrane permeability. Biochem Bioph Res Co 325: 374-380. IF: 2.371

164. Pool, C. T., Boyd, J. G., and Tam, J. P. (2004) Ninhydrin as a reversible protecting group of amino-terminal cysteine. J Pept Res 63: 223-234. 

165. Sadler, K., and Tam, J. P. (2004) Shape-mimetics of G-protein-coupled receptors in therapeutic drug design and screening. Drug Develop Res 62: 336-348. IF: 0.984

166. Zhang, Y., Pool, C., Sadler, K., Yan, H. P., Edl, J., Wang, X. H., Boyd, J. G., and Tam, J. P. (2004) Selection of active ScFv to G-protein-coupled receptor CCR5 using surface antigen-mimicking peptides. Biochemistry 43: 12575-12584. IF: 2.876

167. Li, F. Q. S., Xiao, H., Tam, J. P., and Liu, D. X. (2005) Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus. FEBS Lett 579: 2387-2396.  IF: 3.519

168. Lu, Y. A., and Tam, J. P. (2005) Peptide ligation by a reversible and reusable C-terminal thiol handle. Org Lett 7: 5003-5006.  IF: 6.732

169. Tam, J. P., and Eom, K. D. (2005) Mimicking reverse protein splicing by three-segment tandem peptide ligation. Protein Peptide Lett 12: 743-749. IF: 1.069

170. Li, Q. S., Xiao, H., Tam, J. P., and Liu, D. X. (2006) Sumoylation of the nucleocapsid protein of severe acute respiratory syndrome coronavirus by interaction with Ubc9. Nidoviruses: Toward Control of Sars and Other Nidovirus Diseases 581: 121-126.

171. Liao, Y., Tam, J. P., and Liu, D. X. (2006) Viroporin activity of SARS-CoV E protein. Nidoviruses: Toward Control of Sars and Other Nidovirus Diseases 581: 199-202.

172. Liao, Y., Yuan, Q., Torres, J., Tam, J. P., and Liu, D. X. (2006) Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein. Virology 349: 264-275. IF: 3.2

173. Mu, Y. G., Nordenskiold, L., and Tam, J. P. (2006) Folding, misfolding, and amyloid protofibril formation of WW domain FBP28. Biophys J 90: 3983-3992.  IF: 3.632

174. Tun, T., Sadler, K., and Tam, J. P. (2006) Implementation of a Biosafety Level 3 (BSL3) Facility in Singapore: Requirements, Work Practices, and Procedures- Applied Biosafety. J Am Biol Safety Assoc 11 (not listed in web of science)

175. Wang, L., Tam, J. P., and Liu, D. X. (2006) Biochemical and functional characterization of Epstein-Barr virus-encoded BARF1 protein: interaction with human hTid1 protein facilitates its maturation and secretion. Oncogene 25: 4320-4331. IF: 7.932

176. Yuan, Q., Liao, Y., Torres, J., Tam, J. P., and Liu, D. X. (2006) Biochemical evidence for the prese of the severe acute respiratory protein expressed nce of mixed membrane topologies syndrome coronavirus envelope in mammalian cells. FEBS Lett 580: 3192-3200. IF: 3.519

177. Li, F. Q., Tam, J. P., and Liu, D. X. (2007) Cell cycle arrest and apoptosis induced by the coronavirus infectious bronchitis virus in the absence of p53. Virology 365: 435-445. IF: 3.2

178. Lu, Y. A., Yang, J. L., and Tam, J. P. (2007) epsilon-peptide chimeras as novel antimicrobials. Biopolymers 88: 611-611. IF: 2.248

179. Tun, T., Sadler, K., and Tam, J. P. (2007) Biological Agents and Toxins Act: Development and Enforcement of Biosafety and Biosecurity in Singapore. Applied Biosafety. J Am Biol Safety Assoc. 12 40-44. (not listed in web of science)

180. Yu, Q., Li, L., Lu, Y. A., and Tam, J. P. (2007) Anti-HIV dendrimeric peptides. Biopolymers 88: 603-603. IF: 2.248

181. Huang, D., Korolev, N., Eom, K. D., Tam, J. P., and Nordenskiold, L. (2008) Design and biophysical characterization of novel polycationic epsilon-peptides for DNA compaction and delivery. Biomacromolecules 9: 321-30. IF: 5.583

182. Lu, Y., Liu, D. X., and Tam, J. P. (2008) Lipid rafts are involved in SARS-CoV entry into Vero E6 cells. Biochem Biophys Res Commun 369: 344-9. IF: 2.371

183. Lu, Y., Neo, T. L., Liu, D. X., and Tam, J. P. (2008) Importance of SARS-CoV spike protein Trp-rich region in viral infectivity. Biochem Biophys Res Commun 371: 356-60. IF: 2.371

184. Sadler, K., Zhang, Y., Xu, J., Yu, Q., and Tam, J. P. (2008) Quaternary protein mimetics of gp41 elicit neutralizing antibodies against HIV fusion-active intermediate state. Biopolymers 90: 320-9. IF: 2.248

185. Tam, J. P. (2008) Mutation-resistant antiviral. J Pept Sci 14: 194-194. IF: 1.951

186. Tun, T., Sadler, K., and Tam, J. P. (2008) A Novel Approach for Development and Implementation of an Emergency Response Plan for the BSL-3 Laboratory Service in Singapore. Applied Biosafety. J Am Biol Safety Assoc. 13: 158-163. (not listed in web of science)

187. Chen, B., Fang, S., Tam, J. P., and Liu, D. X. (2009) Formation of stable homodimer via the C-terminal alpha-helical domain of coronavirus nonstructural protein 9 is critical for its function in viral replication. Virology 383: 328-37. IF: 3.2

188. Korolev, N., Berezhnoy, N. V., Eom, K. D., Tam, J. P., and Nordenskiold, L. (2009) A universal description for the experimental behavior of salt-(in)dependent oligocation-induced DNA condensation. Nucleic Acids Res 37: 7137-50. IF: 9.202

189. Ky, N., Lim, C. B., Li, J., Tam, J. P., Hamza, M. S., and Zhao, Y. (2009) KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2). Apoptosis 14: 1095-107. IF: 3.592

190. Lu, Y. A., Yang, J. L., and Tam, J. P. (2009) Epsilon-peptide chimeras as novel antimicrobials. Adv Exp Med Biol 611: 393-4. IF: 1.953

191. Sze, S. K., Wang, W., Meng, W., Yuan, R., Guo, T., Zhu, Y., and Tam, J. P. (2009) Elucidating the structure of cyclotides by partial acid hydrolysis and LC-MS/MS analysis. Anal Chem 81: 1079-88. IF: 5.886

192. Tam, J. (2009) Mutation-Resistant Antivirals. Biopolymers 92: 302-302. IF: 2.248

193. Wang, J., Fang, S., Xiao, H., Chen, B., Tam, J. P., and Liu, D. X. (2009) Interaction of the coronavirus infectious bronchitis virus membrane protein with beta-actin and its implication in virion assembly and budding. PLoS One 4: e4908. IF: 3.057

194. Wang, X., Liao, Y., Yap, P. L., Png, K. J., Tam, J. P., and Liu, D. X. (2009) Inhibition of protein kinase R activation and upregulation of GADD34 expression play a synergistic role in facilitating coronavirus replication by maintaining de novo protein synthesis in virus-infected cells. J Virol 83: 12462-72.  IF: 4.606

195. Yu, Q., Li, L., and Tam, J. P. (2009) Anti-HIV dendrimeric peptides. Adv Exp Med Biol 611: 539-540 IF: 1.953

196. Zhang, H., Guo, T., Li, X., Datta, A., Park, J. E., Yang, J., Lim, S. K., Tam, J. P., and Sze, S. K. (2010) Simultaneous characterization of glyco- and phosphoproteomes of mouse brain membrane proteome with electrostatic repulsion hydrophilic interaction chromatography. Mol Cell Proteomics 9: 635-47. IF: 5.912

197.     Datta, A., Park, J. E., Li, X., Zhang, H., Ho, Z. S., Heese, K., Lim, S. K., Tam, J. P., and
Sze, S.K. (2010) Phenotyping of an in vitro model of ischemic penumbra by iTRAQ
based shotgun quantitative proteomics. J Proteome Res. 9: 472-484. IF: 4.173

198. Eom, K. D., and Tam, J. P. (2011) Acid-catalyzed tandem thiol switch for preparing peptide thioesters from mercaptoethyl esters. Org Lett 13: 2610-3. IF: 6.732

199. Liao, Y., Wang, X., Huang, M., Tam, J. P., and Liu, D. X. (2011) Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus. Virology 420: 106-16. IF: 3.2

200. Nguyen, G. K., Zhang, S., Nguyen, N. T., Nguyen, P. Q., Chiu, M. S., Hardjojo, A., and Tam, J. P. (2011) Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family. J Biol Chem 286: 24275-87. IF: 4.258

201. Nguyen, G. K.T., Zhang, S., Wang, W., Wong, C. T., Nguyen, N. T., and Tam, J. P. (2011) Discovery of a linear cyclotide from the bracelet subfamily and its disulfide mapping by top-down mass spectrometry. J Biol Chem 286: 44833-44. IF: 4.258

202. Sharma, R. K., and Tam, J. P. (2011) Tandem thiol switch synthesis of peptide thioesters via N-S acyl shift on thiazolidine. Org Lett 13: 5176-9. IF: 6.732

203. Wong, C. T., Taichi, M., Nishio, H., Nishiuchi, Y., and Tam, J. P. (2011) Optimal oxidative folding of the novel antimicrobial cyclotide from Hedyotis biflora requires high alcohol concentrations. Biochemistry 50: 7275-83. IF: 2.876

204. Korolev, N., Berezhnoy, N. V., Eom, K. D., Tam, J. P., and Nordenskiöld, L. (2012) A universal description for the experimental behavior of salt-(in)dependent oligocation-induced DNA condensation. Nucleic Acids Res 40: 2808-21. IF: 9.202

205. Korolev, N., Zhao, Y., Allahverdi, A., Eom, K. D., Tam, J. P., and Nordenskiöld, L. (2012) The effect of salt on oligocation-induced chromatin condensation. Biochem Biophys Res Commun 418: 205-10. IF: 2.371

206. Yan, J., Korolev, N., Eom, K. D., Tam, J. P., and Nordenskiöld, L. (2012) Biophysical properties and supramolecular structure of self-assembled liposome/epsilon-peptide/DNA nanoparticles: correlation with gene delivery. Biomacromolecules 13: 124-31. IF: 5.583

207. Zhong, Y., Liao, Y., Fang, S., Tam, J. P., and Liu, D. X. (2012) Up-regulation of Mcl-1 and Bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replication. PLoS One 7: e30191. IF: 3.057

208.     Wong, C. T., Rowlands, D. K., Wong, C. H., Lo, T. W., Nguyen, G. K., Li, H. Y., and Tam, J. P. (2012) Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment. Angew Chem Int Ed Engl 51: 5620-4. DOI: 10.1002/anie.201200984 IF: 11.709

209.   Nguyen, G. K.T., Lim, W. H., Nguyen, P. Q., and Tam, J. P. (2012) Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities. J Biol Chem 287: 17598-17607. DOI: 10.1074/jbc.M111.338970  IF: 4.573

210. Tam, J. P., and Wong, C. T. (2012) Chemical synthesis of circular proteins. J Biol Chem 287: 27020-27025. DOI: 10.1074/jbc.R111.323568  IF: 4.258

211. Nguyen, G. K. T., Lian, Y., Pang, E. W. H., Nguyen, P. Q. T., Tran, T. D., and Tam, J. P. (2013)  Discovery of Linear Cyclotides in Monocot Plant Panicum laxum of the Poaceae Family. Provide New Insights into Evolution and Distribution of Cyclotides in Plants. J Biol Chem 288: 3370-3380. DOI: 10.1074/jbc.M112.415356 IF: 4.258

212.     Hemu, X., Taichi, M., Qiu, Y., Liu, D.-X., and Tam, J.P. (2013) Biomimetic Synthesis of Cyclic Peptides using Novel Thioester Surrogates. Biopolymers(Peptides Science) 100: 492-501. DOI: 10.1002/bip.22308 IF: 2.248

213. Taichi, M., Hemu, X., Qiu, Y., and Tam, J.P. (2013) A thioethylakylamido (TEA) Thioester Surrogate in the Synthesis of a Cyclic Peptide via a Tandem Acyl Shift. Org Lett 15: 2620-2623. DOI: 10.1021/ol400801k IF: 6.732

214. Hao, P., Ren, Y., Tam, J. P., and Sze, S. K. (2013) Correction of Errors in Tandem Mass Spectrum Extraction Enhances Phosphopeptide Identification. J Proteome Res 12: 5548-5557. DOI: 10.1021/pr4004486 IF: 4.173

215. Li, X., Ren Y., Sorokin, V., Poh, K. K., Ho, H. H., Lee, C. N., Kejin, D. de., Lim, S. K., Tam, J. P., and Sze, S. K. (2014) Quantitative Profiling of the Rat Heart Myoblast Secretome Reveals Differential Response to Hypoxia and Re-oxygenation Stress. J Proteomics  98:138-149. DOI: 10.1016/j.jprot.2013.12.025 IF: 3.867

216. Qiu, Y., Hemu, X., Liu, D.X., and Tam, J. P. (2014) Selective Bi-directional Amide Bond Cleavage of N-Methyl Cysteinyl Peptide. Eur J Org Chem 20: 4370-4380. DOI: 10.1002/ejoc.201402261 IF: 3.068

217. Hemu, X., Qiu, Y., and Tam, J. P. (2014) Peptide macrocyclization through amide-to-amide transpeptidation. Tetrahedron. 70: 7707-7713. DOI: 10.1016/j.tet.2014.05.112 IF: 2.645

218. Nguyen, G. K. T., Wang, S., Qiu, Y., Hemu, X., Lian, Y., and Tam, J. P. (2014) Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis. Nat Chem Biol 10: 732-738. DOI: 10.1038/NCHEMBIO.1586 IF: 12.709

219.   Nguyen, P.Q.T., Wang, S., Kumar, A., Yap, L.Y., Luu, T.T., Lescar, J., and Tam, J.P. (2014) Discovery and Characterization of Pseudocyclic Cystine Knot α-Amylase Inhibitors with high resistance to heat and peoteolytic degradation. FEBS J.  281:4351-4366 DOI: 10.1111/febs.12939 IF: 4.237

220.    Dutta, B., Ren, Y., Hao, P., Sim, K. H., Chesro, E., Adav, S., Tam, J. P., and Sze, S. K. (2014) Profiling of the Chromatin-Associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression. Mol Cell Proteomics. 13:2183-2197. DOI: 10.1074/M113.034975 IF: 5.912

221. Dutta, B., Ren, Y., Lim, S. K., Tam, J. P., and Sze, S. K. (2014) Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis. Mol Cell Proteomics. 13(12):3236-49 DOI: 10.1074/M114.038232. IF: 5.912

222. Hao P., Ren, Y., Datta A., Tam, J.P., and Sze, S.K. (2014) Evaluation of the Effect of Trypsin Digestion Buffers on Artificial Deamidation. J Proteome Res. 14: 1308−1314 DOI: 10.1021/pr500903b IF: 4.173

223. Liao, Y., Zhang, S.M., Neo, T.L., and Tam, J.P. (2015) Tryptophan-Dependent Membrane Interaction and Heteromerization with the Internal Fusion Peptide by the Membrane Proximal External Region of SARS-CoV Spike Protein.  Biochemistry. 54: 1819-1830. DOI: 10.1021/bi501352u  IF: 2.876

224. Nguyen, P.Q.T., Luu, T.T., Bai, Y., Nguyen, G.K.T., Pervushin, K., and Tam, J.P. (2015) Allotides: Proline-rich Cystine Knot α-Amylase Inhibitors from the Allamanda cathartica. J Nat Prod 78: 695-704. DOI: 10.1021/np500866c IF: 3.662

225. Yang, H., Shen, Y., Xu, Y., Serra, A., Zheng, J., Wu, Q., and Tam, J.P. (2015). A novel 
strategy for the discrimination of gelatinous Chinese medicines based on enzymatic digestion followed by nano-flow liquid chromatography in tandem with orbitrap mass spectrum detector. Int J Nanomedicine 10: 4947–4955 DOI: 10.2147/IJN.S82291 IF: 4.32

226.      Zhang, S.M., Jejcic, A., Tam, J.P., and Vahlne, A. (2015) Membrane-Active Sequences
Within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing
Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins.
PLoS One. 10(7):e0134851 Published: 31 July 2015. DOI: 10.1371/journal.pone.0134851 IF: 3.057

227.     Kini, S. G., Nguyen, Q. P. T., Weissbach, S., Mallagaray, A., Shin, J., Yoon, H. S., and 
Tam, J.P. (2015). Studies on the Chitin-Binding Property of Novel Cysteine-Rich 
Peptides from Alternanthera sessilis Biochemistry 54 (43), 6639–6649 DOI: 
10.1021/acs.biochem.5b00872 IF: 2.876

228.     Nguyen, G. K. T., Cao Y., Wang W., Liu C.F., and Tam J.P. (2015) Site-specific N-
Terminal Labeling of Peptides and Proteins using Butelase 1 and Thiodepsipeptide.
Angew Chem Int Ed  54 (52), 15694–15698. DOI: 10.1002/anie.201506810 IF: 11.709

229.     Tam, J.P., Wang S., Wong, K.H., and Tan W.L. (2015) Antimicrobial Peptides from 
Plants. Pharmaceuticals 2015, 8(4), 711-757; DOI: 10.3390/ph8040711 No impact
factor yet.

230. Cao Y., Nguyen, G. K. T., Tam, J.P., and Liu, C.F. (2015) Butelase-mediated synthesis
of protein thioesters and its application for tandem chemoenzymatic ligation. Chem
Commun, 51, 17289-17292 DOI: 10.1039/C5CC07227A. IF: 6.567

231. Kumari, G., Serra,  A.,Shin,  J. ,Nguyen, Q. P. T., Sze, S.K., Yoon, H. S., and Tam,  J. P.
(2015) Cysteine-Rich Peptide Family with Unusual Disulfide Connectivity from Jasminum sambac.  J Nat Prod 78 (11), 2791-2799. DOI: 10.1021/acs.jnatprod.5b00762 IF: 3.662

232. Nguyen, P.Q.T, Ooi, J. S. G. Ooi , Nguyen, N.T.K., Wang, S., Huang, M., Liu D.X., and 
Tam, J.P. (2015) Antiviral Cystine Knot -Amylase Inhibitors from Alstonia scholaris. 290
(52), 31138-31150. J Biol Chem DOI: 10.1074/jbc.M115.654855 IF: 4.258

233. Nguyen, G. K. T, Kam, A., Loo, S, Jansson, A.E., Pan, L.X., and Tam, J.P. (2015)
Butelase 1: A versatile ligase for peptide and protein  macro-cyclization.  J Am Chem
Soc 137 (49), 15398–15401. DOI: 10.1021/jacs.5b11014  IF: 13.038

234. Serra, A., Zhu, H., Gallart-Palau, X., Park, J.E., Ho, H.H., Tam, J.P., and Sze, S.K.
(2016) Plasma proteome coverage is increased by unique peptide recovery from
sodium deoxycholate precipitate. Anal Bioanal Chem 408(7): 1963-1973 DOl: 
10.10071s00216-016-9312-7 IF: 3.436

235.     Serra, A., Hemu, X., Nguyen, G.K.T., Nguyen, N.T.K., Sze, S.K., and Tam, J.P. (2016).
A high-throughput peptidomic strategy to decipher the molecular diversity of cyclic
cysteine-rich peptides. Sci Rep. 6: 23005 DOI: 10.1038/srep23005 IF: 5.228

236. Adav, S. S., Gallart-Palau, X., Tan, K. H., Lim, S.K., Tam, J.P., and Sze, S. K. (2016) Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues. Mol Brain 9:20 DOI: 10.1186/s13041-016-0200-z IF: 3.745

237. Nguyen, K.N.T., Nguyen, G. K. T., Nguyen, P.Q.T., Ang, K.H., Dedon, P.C., and Tam, J. P.  (2016) Immunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea). FEBS J.  283 (11): 2067-90 DOI: 10.1111/febs.13720 IF: 4.237

238. Sun, X., Zhang, L., Cao Y., Gu Q., Yang, H., and Tam, J. P. (2016) Quantitative analysis and comparison of four major flavonol glycosides in the leaves of Toona sinensis (A. Juss.) roemer (chinese toon) from various origins by high-performance liquid chromatography-diode array detector and hierarchical clustering analysis. Phcog Mag 12 (46), 270-276 DOI: 10.4103/0973-1296.179660 IF: 0.831

239. Serra, A., Gallart-Palau, X, See-Toh, R. S. E., Hemu, X., Tam, J. P., and Sze, S. K. (2016) Commercial processed soy-based food product contains glycated and glycoxidated lunasin proteoforms. Sci Rep. 6: 26106 DOI: 10.1038/srep26106 IF: 5.228

240. Hemu, X., Qiu, Y., Nguyen, G. K. T., and Tam, J. P. (2016) Total Synthesis of Circular Bacteriocins by Butelase 1. J Am Chem Soc 138 (22):6968-6971 DOI: 10.1021/jacs.6b04310 IF: 13.038

241.     Nguyen G. K. T., Qiu Y., Cao Y., Hemu X., Liu C.F., and Tam J. P. (2016) Butelase mediated cyclization and Ligation of peptides and proteins. Nat Protoc. 11 (10), 1977 – 
1988 DOI:10.1038/nprot.2016.118 IF: 9.646

242.     Lim, Y. X., Ng, Y. L., Tam, J. P., and Liu, D. X. (2016) Human Coronaviruses: A Review 
of Virus-Host Interactions. MDPI Diseases 4 (3), 26 DOI:10.3390/diseases4030026 (no 
impact factor)

243. Nguyen, G. K. T., Hemu, X., Quek, J. P., and Tam, J. P. (2016) Butelase-Mediated 
Macrocyclization of D-Amino Acid-Containing Peptides. Angew Chem Int Ed 4; 55 (41): 12802-6 DOI: 10.1002/anie.201607188 IF: 11.709

244.     Cao, Y., Nguyen, G. K. T., Chuah,S., Tam, J. P., and Liu, C.F. (2016) Butelase 
Mediated Ligation as an Efficient Bioconjugation Method for the Synthesis of Peptide 
Dendrimers Bioconjug Chem 27 (11), 2592-2596 DOI: 10.1021/acs.bioconjchem.6b00538 IF: 4.5

245.  Hemu, X., and Tam, J. P.  (2016) Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin Curr Pharm Des 22 DOI: 10.2174/1381612822666161027120518 IF: 3.052

246.     Qiu, Y., Taichi, M., Wei, N., Yang, H., Luo, K.Q., and Tam, J. P. (2016) An Orally Active 
bradykinin B1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor J Med Chem 60 (1), 504-510 DOI: 10.1021/acs.jmedchem.6b01011 IF: 5.589

247.    Wong, K. H., Tan, W. L., Serra,  A., Xiao, T., Sze, S. K., Yang, D., and Tam J. P. (2016) Ginkgotides: Proline-Rich Hevein-Like Peptides from Gymnosperm Ginkgo biloba Front. Plant Sci 7: 1639 DOI: 10.3389/fpls.2016.01639 IF: 4.495

248. Yang, H., Yin, H., Shen, Y., Xia, G., Zhang, B., Wu, X., Cai, B., and Tam, J. P. (2016) A 
More ecological and efficient approach for producing diosgenin from Dioscorea
zingiberensis tubers via pressurized biphase acid hydrolysis J Clean Prod 131, 10-19 DOI:10.1016/j.jclepro.2016.05.030 IF: 4.959

249.     Loo, S., Kam, A., Xiao, T., Nguyen, G. K. T., Liu, C. F., and Tam, J. P. (2016)
Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa Sci Rep 6: 39401 DOI:10.1038/srep39401 IF: 5.228

250.     Park, J. E., Sun, Y., Lim, S. K., Tam, J. P., Dekker, M., Chen, H., and Sze, S. K. (2017) 
Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers Sci Rep 7: 40569 DOI: 10.1038/srep40569 IF: 5.228

251. Shen, Y., Xu, M., Deng, P., Gu, Q., Yin, H., Xia, G., Jia, X., Yang, H., Tam, J.P. (2017) Establishment of a Rapid Method to Quantify Eight Flavonol Glycosides for Quality Assessment of Red Toon Using UPLC. Acta Chromatogr 30: 31–37 DOI: 10.1556/1326.2017.00189 IF: 0.773

252.     Yang, R., Wong, Y. H., Nguyen, G. K., Tam, J. P., Lescar, J., and Wu, B. (2017) 
Engineering a Catalytically Efficient Recombinant Protein Ligase. J Am Chem Soc 139: 5351–5358 DOI: 10.1021/jacs.6b12637 IF: 13.038

253.     Kini, S. G., Wong, K. H., Tan, W. L., Xiao, T., and Tam, J. P. (2017) Morintides: Cargo-
Free Chitin-binding Peptides from Moringa oleifera BMC Plant Biology 17:68 DOI: 10.1186/s12870-017-1014-6 IF: 4.085

254.     Bi, X., Yin, J., Nguyen, G. K. T., Rao, C., Halim, N. B. A., Hemu, X., Tam, J. P., Liu, C. F. (2017) Enzymatic engineering of live bacterial cell surface using butelase 1 Angew Chem Int Ed. 56:7822-7825 DOI: 10.1002/anie.201703317 IF: 11.709

255. Wong, K. H., Tan, W. L., Kini, S. G., Xiao, T., Serra. A., Sze, S. K., Tam, J. P. (2017) Vaccatides: Antifungal Glutamine-Rich Hevein-like Peptides from Vaccaria hispanica Front. Plant Sci. 8:1100 DOI: 10.3389/fpls.2017.01100 IF: 4.298

256. Tan, W. L., Wong, K. H., Xiao, T., Tam, J. P. (2017) Lybatides from Lycium barbarum Contain an Unusual Cystine-stapled Helical Peptide Scaffold Sci. Rep. 7:5194 DOI: 10.1038/s41598-017-05037-1 IF: 4.259

257. Wong, K. H., Tan, W. L., Xiao, T., Tam, J. P. (2017) β-Ginkgotides: Super-constrained cysteine-rich peptides from Ginkgo biloba Sci. Rep. 7:6140 DOI: 10.1038/s41598-017-06598-x IF: 4.259

258. Loo, S., Kam, A., Xiao, T, Tam, J. P. (2017) Bleogens: Cactus-derived Anti-Candida Cysteine-rich Peptides with Three Different Precursor Arrangements Front. Plant Sci. 8:2162 DOI: 10.3389/fpls.2017.02162 IF: 4.298

259. Shen, Y., Wang, H., Yi, L., Xu, L., Yin, H., Tam, J.P., Yang, H., Jia, X., (2018) Construction of a novel catalysis system for clean and efficient preparation of Baohuoside I from Icariin based on biphase enzymatic hydrolysis J Clean Prod  170: 727-734 DOI: 10.1016/j.jclepro.2017.09.192 IF: 4.959

260. Zhang, S. M., Liao, Y., Neo, T.L., Lu, Y., Liu, D. X., Vahlne, A., Tam, J.P. (2018) Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein Int J Biochem Cell Biol. 101:103-112 DOI: 10.1016/j.biocel.2018.05.012 IF: 4.240

261. Shen, Y., Wang, H., Yi, L., Xu, L., Yin, H., Tam, J.P., Yang, H., Jia, X., (2018) A Novel PCR-based Technology for Rapid and Non-Sequencing Authentication of Bombyx Batryticatus using Species-specific Primers Nat Prod Res  1478-6427 DOI: 10.1080/14786419.2018.1466127 IF: 1.828

262. Bi, X., Yin, J., Hemu, X., Rao, C., Tam, J.P., Liu, C.F. (2018) Immobilization and Intracellular Delivery of Circular Proteins by Modifying a Genetically Incorporated Unnatural Amino Acid Bioconjug Chem 29:2170–2175 DOI: 10.1021/acs.bioconjchem.8b00244 IF: 4.818

263. Kumari, G., Wong, K.H., Serra, A., Shin, J., Yoon, H.S., Sze, S.K., Tam, J.P. (2018) Molecular diversity and function of jasmintides from Jasminum sambac BMC Plant Biology 18:144 DOI: 10.1186/s12870-018-1361-y IF: 3.964

264. Serra, A., Gallart-Palau, X., Park, J.E., Lim, G., Lim, K.L., Ho, H.H., Tam, J.P., Sze, S.K. (2018) Vascular Bed Molecular Profiling by Differential Systemic Decellularization In Vivo Arterioscler. Thromb. Vasc. Biol. DOI: 10.1161/ATVBAHA.118.311552 IF: 6.607

265. Shen, Y., Xu, M., Deng, P., Gu, Q., Yin, H., Xia, G., Jia, X., Yang, H., Tam, J.P. (2018) Establishment of a rapid method to quantify eight flavonol glycosides for quality assessment of Red Toon using UPLC Acta Chromatographica 38:2396–2409 DOI: 10.1556/1326.2017.00189 IF: 0.773

266. Harmand, T., Bousbaine, D., Chan, A. I., Zhang, X., Liu, D.R., Tam, J.P., Ploegh, H. L. (2018) One-pot dual labeling of an IgG 1 and preparation of C-to-C fusion proteins through a combination of Sortase A and Butelase 1 Bioconjug Chem  29:3245–3249 DOI: 10.1021/acs.bioconjchem.8b00563 IF: 4.485

267. Tam, J.P., Nguyen, G. K. T., Loo, S., Wang, S., Yang, D., Kam, A. (2018) Ginsentides: Cysteine and Glycine-rich Peptides from the Ginseng Family with Unusual Disulfide Connectivity Sci. Rep. 8:16201 DOI: 10.1038/s41598-018-33894-x IF: 4.122

268. Shen, Y., Wang, M., Chen, Y., Xu, L., Lu, Y., Zhou, Y., Tam, J. P., Han, F., Yang, H., Jia, X. (2019) Convenient preparation of sagittatoside B, a rare bioactive secondary flavonol glycoside, by recyclable and integrated biphase enzymatic hydrolysis Enzyme Microb. Technol. 121:51-58 DOI: 10.1016/j.enzmictec.2018.12.002 IF: 2.287

269. Kam, A., Loo, S., Dutta, B., Sze, S. K., Tam, J. P. (2019) Plant-derived Mitochondria-targeting Cysteine-rich Peptide Modulates Cellular Bioenergetics J Biol Chem DOI: 10.1074/jbc.RA118.006693 IF: 4.010

270. Huang, J., Wong, K. H., Tay, S., Serra, A., Sze, S. K., Tam, J. P. (2019) Astratides: insulin-modulating, insecticidal and antifungal cysteine-rich peptides from Astragalus membranaceus J. Nat. Prod. 82:194–204 DOI: 10.1021/acs.jnatprod.8b00521 IF: 3.885

271. Hemu, X., Zhang, X., Tam, J. P. (2019) Ligase-controlled Cyclo-oligomerization of Peptides Org. Lett 21:2029–2032 DOI: 10.1021/acs.orglett.9b00151 IF: 6.492

272. Park, J. E., Tse, S. W., Guo, X., Assisi, C., Serra, A., Ramon, G. P. X., Low, J. K., Oi, L. K., Tay, C. Y., Tam, J. P., Sze, S. K. (2019) Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression Oncotarget 10:2136-2150 DOI:  10.18632/oncotarget.26669 IF: 5.168 

273. Shen, Y., Xu, L., Huang, J., Serra, A., Yang, H., Tam, J.P. (2019) Potentides: Novel Cysteine-Rich Peptides with Unusual Disulfide Connectivity from Potentilla anserina ChemBioChem DOI: 10.1002/cbic.201900127 IF: 2.774 [Epub, no page number yet]

274. Sze, S.K., Jung, E.P., Dutta, B., Tse, S.W., Gupta, N., Tan, C.F., Low, J.K., Yeoh, K.W., Koh, O.L., Tam, J.P. (2019) Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift Oncogene DOI: 10.1038/s41388-019-0782-x IF: 6.854

275. Ouyang, Q., Feng, X., Kuang, S., Panwar, N., Song, N., Yang, C., Yang, G., Hemu, X., Zhang, G., Yoon, H. S., Tam, J. P., Liedberg, B., Zhu, G., Yong, K. T., Wang, Z. (2019) Self-powered, on-demand transdermal drug delivery system driven by triboelectric nanogenerator NANO ENERGY. IF: 13.120 (Accepted)​

276. Hemu, X., El Sahili, A., Hu, S., Wong, K. H., Chen, Y., Wong, Y. H., Zhang, X., Serra, A., Goh, B. C., Darwis, D. A., Chen, M. W., Sze, S. K., Liu, C. F., Lescar, J., Tam, J. P. (2019) Structural determinants for peptide-bond formation by asparaginyl ligases PNAS DOI: IF: 10.4

277. Wong, Y. H., Thao, H. P., Chen, Y., El Sahili, A., Chai, Y. T., Tam, J. P., Wu, B., Lescar, J. (2019) Structure-based design of a recombinant Asn ligase with altered substrate specificity and its use for sequential protein ligation J. Am. Chem. Soc. IF: 14.357 (Submitted)

278. Bi, X., Yin, J., Zhang, D., Zhang, X., Balamkundu, S., Lescar, J., Dedon, P. C., Tam, J. P., Liu, C. F. (2019) Tagging Transferrin Receptor with a Disulfide FRET Probe to Gauge the Redox State in Endosomal Compartments Angew Chem Int Ed. DOI: IF: 12.102 (Submitted)

279. Huang, J., Wong, K. H., Tay, S. V. Tam, J. P. (2019) Cysteine-rich peptide fingerprinting: A rapid method to differentiate Radix Astragali from Radix Hedysarum IF: 3.679 (Submitted)

280. Loo, S., Kam, A., Li, B. B., Feng, N., Wang, X., Tam, J. P. (2019) Plant-derived Epidermal Growth Factor Receptor Agonist Nat. Commun. DOI: IF: 12.353 (Under review)

281. Wong, K. H., Hemu, X., Nguyen, G. K. T., Chen, Y., Chan, N. Y., Huang, M., Hu, S., Serra, A., Sze, S. K., Lescar, J., Tam, J. P. (2019) Molecular Basis of Plant Peptide Asparaginyl Ligases PNAS USA DOI: IF: 9.504 (Under review)