Su I-Hsin


Selected Publications

  1. Gunawan M., Venkatesan N., Loh  JT., Wong JF., Berger H., Neo WH., Li LY., Khun La Win M., Yau YH., Guo T., See CE.,Yamazaki S., Chin KC.,Gingras AR.,Shochat SG., Ng, LG., Sze SK., Ginhoux F. & Su I-H,* The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nature Immunology, cover story, 16:505–516:(2015) * Corresponding author
  2. Neo WH., Lim JF., Grumont R., Gerondakis S., Su I-H.*, c-Rel Regulates Ezh2 Expression in Activated Lymphocytes and Malignant Lymphoid Cells. J Biol Chem 2014 * Corresponding author
  3. Neo WH., Yap K., Lee SH., Looi LS., Khandelia P., Neo SX., Makeyev E., Su I-H.* MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression. J Biol Chem 2014; 289(30): 20788–20801 * Corresponding author
  4. Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C, Kitamura D, Toellner KM, Su I-H, Casola S. “Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis”. J Clin Invest 2013; 123(12): 5009-5022
  5. Chan Y-S, Göke J, Lu X,  Venkatesan N, Feng B, Su I-H*, Ng H-H*A PRC2 dependent repressive role of PRDM14 in human embryonic stem cells and iPSC reprogramming” Stem cell 2013. 31(4):682-692 * Corresponding authors.
  6. Wyngaarden LA, Delgado-Olquin P, Su I-H, Bruneau BG, Hopyan S. Ezh2 regulates ateroposterior axis specification and proximodistal axis elongation in the develop limb. Development 2011, 138, 3759-3767
  7. Wang L, Jin Q, Lee JE, Su I-H, Ge K. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A. 2010, 107(16):7317-22.
  8. Xu S, Huo J, Gunawan M, Su I-H, Lam KP. Activated dectin-1 localizes to lipid raft microdomains for signaling and activation of phagocytosis and cytokine production in dendritic cells. J Biol Chem, 2009,284(33):22005-11
  9. Chen N., Gu, X., Su,  I-H., Bottino, R., Contreras, J.L. Tarakhovsky A., Kim S-K., Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regneration in diabetes mellitus. Genes & Development, 2009, 23(8):975-85.
  10. Ezhkova E., H. Pasolli A., Parker J., Stokes N., Su I-H., Hannon G., Tarakhovsky A., Fuchs E. Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue Specific Stem Cells. Cell 2009, 136, 1122-1135.
  11. Su I-H.* and Tarakhovsky A*. Lysine methylation and “signaling memory“ Curr. Op. Immunol. 2006, Apr;18(2):152-7. * Corresponding authors
  12. Su I-H.*, Dobeneker MW., Dickinson E., Oser M., Basavaraj A., Margueron R., Viale A., Reinberg D., Wülfing C., Tarakhovsky A.* Polycomb group protein Ezh2 controls actin polymerization and cell signaling. Cell 2005, 121:425-436. * Corresponding authors
  13. Su I-H.* and Tarakhovsky A*. Epigenetic control of B cell differentiation. Semin. Immunol. 2005; 17: 167-172. * Corresponding authors
  14. Erhardt S., Su I-H., Schneider R., Barton S., Bannister A.J., Perez-Burgos L., Jenuwein T, Kouzarides T., Tarakhovsky A., Surani M.A. Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 2003; 130: 4235-4248.
  15. Saijo K., Schmedt C., Su I-H., Karasuyama H., Reth M., Patke A., Santana A., Tarakhovsky A. Essential role of Src-family protein tyrosine kinases in NF-kB activation during B cell development. Nature Immunology 2003; 4:274-279.
  16. Su I-H., Basavaraj A., Krutchinsky A., Hobert O., Ullrich A., Chait B., Tarakhovsky A.* Ezh2 controls B cell development through histone H3 methylation and IgH gene rearrangement. Nature Immunology 2003; 4: 124-131.
  17. Yokoyama K., Su I-H., Tezuka T., Yasuda T., Mikoshiba K., Tarakhovsky A., and Yamamoto, T. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor. EMBO 2002; 21: 83-92.
  18. Ogata H.*, Su I-H.*, Miyake K., Nagai Y., Akashi S., Mecklenbräuker I., Rajewsky K. and Tarakhovsky A. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 2000; 192: 23-29. * These authors contributed equally to this work.
  19. Su I-H. and Tarakhovsky A. B-1 Cells: Orthodox or conformist? Curr. Op. Immunol. 2000; 12: 191-194.
  20. Texido G.*, Su I-H.*, Mecklenbräuker I., Saijo K., Malek S.N., Desiderio S.V., Rajewsky K., Tarakhovsky A. The B-Cell-Specific src-Family Kinase Blk is Dispensable for B-Cell Development and Activation. Mol. Cell. Biol. 2000; 20: 1227-33. * These authors contributed equally to this work.
  21. Chan V.W.F., Mecklenbräuker I., Su I-H., Texido G., Leitges M., Carsetti R., Lowell C.A., Rajewsky K., Miyake K. and Tarakhovsky A. The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105. J. Exp. Med. 1998; 188: 93-101.