Su I-Hsin


Selected Publications

  1. Venkatesan, N., Wong, J. F., Tan, K. P., Chung, H. H., Yau, Y. H., Cukuroglu, E., Allahverdi, A., Nordenskiold, L., Goke, J., Geifman-Shochat, S., Lin, V. C. L., Madhusudhan, M. S., and Su, I. H. (2018) EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms. Oncogene 37, 461-477
  2. Loh, J. T., Lim, T. J. F., Ikumi, K., Matoba, T., Janela, B., Gunawan, M., Toyama, T., Bunjamin, M., Ng, L. G., Poidinger, M., Morita, A., Ginhoux, F., Yamazaki, S., Lam, K. P., and Su, I. H. (2018) Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells. iScience 10, 23-39
  3. Lim, T. J. F., and Su, I. H. (2018) Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality. J Immunol 201, 3651-3661
  4. Evrard, M., Kwok, I. W. H., Chong, S. Z., Teng, K. W. W., Becht, E., Chen, J. M., Sieow, J. L., Penny, H. L., Ching, G. C., Devi, S., Adrover, J. P. M., Li, J. L. Y., Liong, K. H., Tan, L., Poon, Z., Foo, S., Chua, J. W., Su, I. H., Balabanian, K., Bachelerie, F., Biswas, S. K., Larbi, A., Hwang, W. Y. K., Madan, V., Koeffler, H. P., Wong, S. C., Newell, E. W., Hidalgo, A., Ginhoux, F., and Ng, L. G. (2018) Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions. Immunity 48, 364-379
  5. Gunawan, M., Venkatesan, N., Loh, J. T., Wong, J. F., Berger, H., Neo, W. H., Li, L. Y. J., La Win, M. K., Yau, Y. H., Guo, T., See, P. C. E., Yamazaki, S., Chin, K. C., Gingras, A. R., Shochat, S. G., Ng, L. G., Sze, S. K., Ginhoux, F., and Su, I. H. (2015) The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nature Immunology 16, 505-516
  6. Neo, W. H., Yap, K., Lee, S. H., Looi, L. S., Khandelia, P., Neo, S. X., Makeyev, E. V., and Su, I. H. (2014) MicroRNA miR-124 Controls the Choice between Neuronal and Astrocyte Differentiation by Fine-tuning Ezh2 Expression. Journal of Biological Chemistry 289, 20788-20801
  7. Neo, W. H., Lim, J. F., Grumont, R., Gerondakis, S., and Su, I. H. (2014) c-Rel Regulates Ezh2 Expression in Activated Lymphocytes and Malignant Lymphoid Cells. Journal of Biological Chemistry 289, 31693-31707
  8. Chan, Y. S., Goke, J., Lu, X. Y., Venkatesan, N., Feng, B., Su, I. H., and Ng, H. H. (2013) A PRC2-Dependent Repressive Role of PRDM14 in Human Embryonic Stem Cells and Induced Pluripotent Stem Cell Reprogramming. Stem Cells 31, 682-692
  9. Caganova, M., Carrisi, C., Varano, G., Mainoldi, F., Zanardi, F., Germain, P. L., George, L., Alberghini, F., Ferrarini, L., Talukder, A. K., Ponzoni, M., Testa, G., Nojima, T., Doglioni, C., Kitamura, D., Toellner, K. M., Su, I. H., and Casola, S. (2013) Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. Journal of Clinical Investigation 123, 5009-5022
  10. Wyngaarden, L. A., Delgado-Olguin, P., Su, I. H., Bruneau, B. G., and Hopyan, S. (2011) Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development 138, 3759-3767
  11. Wang, L. F., Jin, Q. H., Lee, J. E., Su, I. H., and Ge, K. (2010) Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proceedings of the National Academy of Sciences of the United States of America 107, 7317-7322
  12. Xu, S. L., Huo, J. X., Gunawan, M., Su, I. H., and Lam, K. P. (2009) Activated Dectin-1 Localizes to Lipid Raft Microdomains for Signaling and Activation of Phagocytosis and Cytokine Production in Dendritic Cells. Journal of Biological Chemistry 284, 22005-22011
  13. Ezhkova, E., Pasolli, H. A., Parker, J. S., Stokes, N., Su, I. H., Hannon, G., Tarakhovsky, A., and Fuchs, E. (2009) Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells. Cell 136, 1122-1135
  14. Chen, H. A., Gu, X. Y., Su, I. H., Bottino, R., Contreras, J. L., Tarakhovsky, A., and Kim, S. K. (2009) Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes & Development 23, 975-985
  15. Su, I. H., and Tarakhovsky, A. (2006) Lysine methylation and 'signaling memory'. Current Opinion in Immunology 18, 152-157
  16. Su, I. H., and Tarakhovsky, A. (2005) Epigenetic control of B cell differentiation. Seminars in Immunology 17, 167-172
  17. Su, I. H., Dobenecker, M. W., Dickinson, E., Oser, M., Basavaraj, A., Marqueron, R., Viale, A., Reinberg, D., Wulfing, C., and Tarakhovsky, A. (2005) Polycomb group protein Ezh2 controls actin polymerization and cell signaling. Cell 121, 425-436
  18. Su, I. H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T., and Tarakhovsky, A. (2003) Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nature Immunology 4, 124-131
  19. Saijo, K., Schmedt, C., Su, I. H., Karasuyama, H., Lowell, C. A., Reth, M., Adachi, T., Patke, A., Santana, A., and Tarakhovsky, A. (2003) Essential role of Src-family protein tyrosine kinases in NF-kappa B activation during B cell development. Nature Immunology 4, 274-279
  20. Erhardt, S., Su, I. H., Schneider, R., Barton, S., Bannister, A. J., Perez-Burgos, L., Jenuwein, T., Kouzarides, T., Tarakhovsky, A., and Surani, M. A. (2003) Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130, 4235-4248
  21. Yokoyama, K., Su, I. H., Tezuka, T., Yasuda, T., Mikoshiba, K., Tarakhovsky, A., and Yamamoto, T. (2002) BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor. Embo Journal 21, 83-92
  22. Texido, G., Su, I. H., Mecklenbrauker, I., Saijo, K., Malek, S. N., Desiderio, S., Rajewsky, K., and Tarakhovsky, A. (2000) The B-cell-specific src-family kinase Blk is dispensable for B-cell development and activation. Molecular and Cellular Biology 20, 1227-1233
  23. Su, I. H., and Tarakhovsky, A. (2000) B-1 cells: orthodox or conformist? Current Opinion in Immunology 12, 191-194
  24. Ogata, H.,Su, I. H., Miyake, K., Nagai, Y., Akashi, S., Mecklenbrauker, I., Rajewsky, K., Kimoto, M., and Tarakhovsky, A. (2000) The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. Journal of Experimental Medicine 192, 23-29
  25. Chan, V. W. F., Mecklenbrauker, I., Su, I. H., Texido, G., Leitges, M., Carsetti, R., Lowell, C. A., Rajewsky, K., Miyake, K., and Tarakhovsky, A. (1998) The molecular mechanism of B cell activation by toll-like receptor protein RP-105. Journal of Experimental Medicine 188, 93-101