Li Hoi Yeung


Selected Publications

  1. Chan, K.S., Koh, C.G., and Li H.Y. (2012). Mitosis-targeted anti-cancer therapies: where they stand. Cell Death and Disease, 3, e411; doi:10.1038/cddis.2012.148
  2. Lee, Y.P., Wong, C.H., Chan, K.S., Lai, Koh, C.G., and Li H.Y. (2012). In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochores-microtubules attachments via Aurora B Kinase. PLOS One, 7(9): e45836. doi:10.1371/journal.pone.0045836
  3. Wong, C.T.T., Rowlands, D.K., Wong, C.Y., Lo T.W.C., Nguyen, G.K.T., Li, H.Y., Tam, J.P. (2012) Orally active peptidic Bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment. Angewandte Chemie, 51(23), 5620-5624
  4. Chuang, L.S.H., Lai, S.K., Murata-Hori, M., Yamada, A., Li, H.Y., Gunaratne, J. and Ito, Y. (2012) RUNX3 interatome reveals noval centrosomal targeting of RUNX family of transcription factors. Cell Cycle 11(10): 1938-1947
  5. Huang, R. L., Teo, Z.Q., Chong, H.C., Zhu, P.C., Tan, M.J., Tan, C.K., Lam, C.R.I., Sng, M.K., Leong D.W.T., Tan, S.M., Kersten, S., Ding, J.L., Li, H.Y. and Tan, N.S. (2011). ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters. Blood 118(14):3990-4002. doi:10.1182/blood-2011-01-328716
  6. Zhu, P.C., Tan, M.J., Huang, R-L, Tan, C.K., Chong, H.C., Pal, M., Lam, C.R.I., Boukamp, P., Pan, J.Y., Tan, S.H., Kersten, S., Li, H.Y., Ding, J.L. and Tan, N.S. (2011). Angiopoietin-like 4 proteins elevates the pro-survival intracellular O2-:H2O2 ratio and confers anoikis resistance to tumor. Cancer Cell 19:401-415.
  7. Chan W.M., Tsoi H., Wu, C.C., Wong, C.H., Cheng, T.C., Li, H.Y., Lau, K.F., Shaw, P.C., Perrimon, N., and Chan, H.Y.E. (2011), Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Human Molecular Genetics 20;1738-1750
  8. Lai, S.K., Wong, C.H., Lee, Y.P. and Li, H.Y. (2011). Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death. Cell Death and Differentiation 18(6); 996-1004.
  9. Chan, K.S.K, Wong, C.H., Huang, Y.F. and Li, H.Y. (2010). Survivin withdrawal via nuclear export failure as a physiological switch to commit cells to apoptosis. Cell Death and Disease, 1, e57.
  10. Ho, C.Y. and Li, H.Y. (2010). DNA damage during mitosis invokes a JNK-mediated stress response that leads to cell death. Journal of Cellular Biochemistry, 1, 110(3), 725-31
  11. Fung, W.T. Beyzavi, A., Abgrall, P., Nguyen, N.T., and Li, H.Y. (2009). Microfluidic platform for controlling the differentiation of embryoid body, Lab on a Chip, 9, 2591-2595
  12. Wong, C.H., Chan H., Ho, C.Y., Lai S.K., Chan K.S.K, Koh, C.G., and Li, H.Y. (2009). Apoptotic histone modification inhibits the nuclear transport by regulating RCC1. Nature Cell Biology, 11:36-45. This article has been highlighted in the “News and View” of the journal and in Faculty of 1000 Biology.
  13. Ho, C.Y., Wong, C.H. and Li, H.Y. (2008). Perturbation of the chromosomal binding of RCC1, Mad2 and Survivin causes spindle assembly defects and mitotic catastrophe. Journal of Cellular Biochemistry,105(3):835-46.
  14. Huang, Y.F., Wu, M., and Li. H.Y. (2008). Tumor suppressor ARF promotes non-classic proteasomal independent polyubiquitination of COMMD1. Journal of Biological Chemistry, 283(17):11453-11460.
  15. Vararattanavech, A., Tang, M.L., Li, H.Y., Wong, C.H., Law, S.K. Alex,Torres, J., and Tan, S.M. (2007). Permissive transmembrane heterodimerization is required for the expression of a functional integrin. Biochemical Journal, 410(3):495-502.
  16. Li, H.Y., Ng, W.P. Wong, C.H., Iglesias, P., and Zheng, Y. (2007). Coordination of chromosome alignment and mitotic progression by the chromosome-based Ran signal. Cell Cycle, 6:1886-1895.
  17. Vong, Q.P.Y., Cao, K., Li, H.Y.., Iglesias, P., and Zheng, Y. (2005). Chromosome alignment and segregation regulated by ubiquitination of Survivin.Science, 310: 1499-1504.
  18. Li, H.Y., Zheng, Y. (2004). The production and localization of GTP-bound Ran in mitotic mammalian tissue culture cells. Cell Cycle, 3(8).
  19. Li, H.Y., Zheng, Y. (2004). Mitotic phosphorylation of RCC1 is essential for producing a high RanGTP concentration on chromosomes and spindle assembly in mammalian cells. Genes & Development, 18:512-527.
  20. Li, H.Y., Cao, K., Zheng, Y. (2003). Ran in the spindle checkpoint: a new function for a versatile GTPase, Trends in Cell Biology, 13: 553-55.
  21. Li, H.Y., Wirtz, D., Zheng, Y. (2003). A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo. The Journal of Cell Biology, 160: 635-644.
  22. Kotaka, M , Lau, Y.M., Cheung, K.K., Lee, S.M.Y., Li, H.Y., Chan, W.Y., Fung, K.P., Lee, C.Y., Waye, M.M.Y., Tsui, S.K.W. (2002) Elfin is expressed during early heart development. Journal of Cellular Biochemistry, 82(1):1-10.
  23. Ng, K.O.E., Lee, S.M.Y., Li, H.Y., Tsui, S.K.W., Waye, M.M.W., Lee, C.Y., and Fung, K.P.(2001). Characterization of a tissue-specific LIM domain protein (FHL1C) which is another alternatively spliced isoform of human LIM-only protein FHL1. Journal of Cellular Biochemistry, 83(3):463-472
  24. Li, H.Y., Kotaka, M., Kostin, S.,Lee, S.M.Y., Kok, L.,D,S., Chan, K.K., Stephen Tsui, S.K.W., Schaper, J., Lee, C.Y., Fung, K.P., Waye, M.M.Y. (2001) Translocation of a human focal adhesion LIM-only protein, FHL2, during myofibrillogenesis and identification of LIM2 as the principal determinants of FHL2 focal adhesion localization. Cell Motility and the Cytoskeleton,48(1):11-23.
  25. Li, H.Y., Ng, E.K.O., Lee, S.M.Y., Kotaka,M., Chan, K.K., Stephen Tsui, S.K.W., Lee, C.Y., Fung, K.P., Waye, M.M.Y. (2001) Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET). Journal of Cellular Biochemistry, 80(3):293-303.
  26. Kotaka, M., Kostin, S., Cheung, K.K., Li, H.Y., Ngai S.M., Lee, S.M.Y., Chan, K.K., Chan, W.Y., Schaper, J., Tsui, S.K.W., Fung, K.P., Lee, C.Y., and Waye, M.M.Y. (1999). The interaction of hCLIM1, a developmentally regulated LIM protein, with a-Actinin 2. Journal of Cellular Biochemistry, 78(4):558-65.
  27. Lee, S.M.Y., Li, H.Y., Or, S.M.W., Chan, K.K., Kotaka, M., Chim, S.S.C., Tsui, S.K.W., Waye, M.M.Y., Fung, K.P., and Lee, C.Y. (1999) Characterization of a brain-specific nuclear LIM domain protein (FHL1B) which is an alternatively spliced variant of FHL1. Gene, 237;253-263.
  28. Lee, S.M.Y., Tsui, S.K.W., Chan, K.K., Kotaka, M., Li, H.Y., Waye, M.M.Y., Fung, K.P., and Lee, C.Y. (1998) Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to human chromosome 1p34. Somatic Cell and Molecular Genetics, 24: 197-202.