Yoon Ho Sup, Joe


Selected Publications

  1. Yoon, H.S., Hajduk, P.T., Petros, A.M., Olejniczak, E.T., Meadows, R.P., and Fesik, S.W. (1994) Solution structure of a Pleckstrin homology (PH) domain. Nature 369, 672-675.
  2. Harlan, EJ., Hajduk, PT, Yoon, HS, and Fesik, SW (1994) Pleckstrin homology domains bind to phosphatidylinositol 4,5-bisphosphate. Nature 371, 168-170.
  3. Muchmore, S.W., Sattler, M., Liang, H., Meadows, R.P., Harlan, J.E., Yoon, H.S., Nettesheim, D., Chang, B.S., Thompson, C.B., Wong, S.-L., Ng, S.-C., and Fesik, S.W. (1996) X-ray and NMR structure of Bcl-XL, an inhibitor of programmed cell death. Nature 381, 335-341.
  4. Sattler, M., Liang, H., Nettesheim, D., Meadows, R.P., Harlan, J.E., Eberstadt, M., Yoon, H.S., Shuker, S.B., Chang, B., Minn, A.J., Thompson, C.B., and Fesik, S.W. (1997) Structure of Bcl-XL-Bak peptide complex: Recognition between regulators of apoptosis. Science 275, 983-986.
  5. Petros, A.M, Medek, A., Nettesheim, D. G., Kim, D.H., Yoon, H.S., Swift, K., Matayoshi, E.D.,Oltersdorf, T., and Fesik, S.W. (2001) Solution Structure of The Anti-Apoptotic Protein Bcl-2. Proc. Natl. Acad. Sci. USA 98, 3012-3017.
  6. Kang, C.B., Tai, J, Chia, J., and Yoon, HS (2005) Flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38) FEBS Letters 579, 1469-1476.
  7. Wang, Y, Gao, S, Ye, W, Yoon, HS, and Yang, Y (2006) Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer. Nature Materials 5, 791-796.
  8. Kang, T.H., Park, DY., Choi, YH., Kim, KJ., Yoon, HS, and Kim, KT (2007) Mitotic histone phosphorylation by VRK1 in mammalian cells. Mol. Cell. Biol. 27, 8533-8546.
  9. Kang, CB, Ye, H, Yoon, HR., and Yoon, HS. (2008) Solution structure of FK506-binding domain (FKBD) of Plasmodium falciparum FK506-Binding Protein 35 (PfFKBP35). PROTEINS: Structure, Function, and Bioinformatics 70, 300-302.
  10. Xu, H, Ye, H, Osman, NE, Sadler, K, Won, EY, Chi, SW, Yoon, HS (2009) The MDM2-binding region in the transactivation domain of p53 also acts as a Bcl-XL-binding motif. Biochemistry 48, 12159-12168.
  11. Choi, BH, Feng, L and Yoon, HS (2010) FKBP38 Protects Bcl-2 from Caspase-dependent degradation. J. Biol. Chem. 285, 9770-9779.
  12. Won, EY, Jang, M, Lee, DH, Ryu, KS, Bae, KH, Park, BC, Yoon, HS*, and Chi, SW* (2011) Molecular-mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins. J. Am. Chem. Soc. 133, 1244-1247 (*co-corresponding author).
  13. Shin, J, Chakraborty, G, Bharatham, N, Tochio, N, Koshiba, S, Kigawa, T, Kim, W, Kim, KT, Yoon, HS (2011) NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for structural stability and autocatalytic activity. J. Biol. Chem.286, 22131-22138.
  14. Kim W, Chakraborty G, Park CH, Kim S, Jeong MW, Bharatham N, Shin J, Yoon HS and Kim KT (2012) MacroH2A1 suppresses mitotic kinase VRK1 during interphase. J. Biol. Chem. 287, 5278-5289.
  15. He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Nagakumar B, Li B,Oh S, Lee WH, Takahashi Y, Wang HG, Deretic V, Pepperkok R, Tagaya M, Yoon HS, and Chengyu Liang (2013) PI(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the Beclin1 complex. Nature Cell Biology15, 1206-1219.
  16. Kang CB, Hong Y, Chia J, Choi BH, Simon B, Schütz U, Sattler M and Yoon HS (2013) Functional role of the N-terminal extension of FKBP38 in catalysis. Sci. Rep. 2013 Oct 18; 3: 2985. doi: 10.1038/srep02985.
  17. Amaravadhi H, Baek K and Yoon HS (2014) Revisiting de novo based drug design: Receptor based pharmacophore screening. Curr. Top. Med. Chem. 14, 1890-1898.
  18. Kim CH, Han, BS, Moon J, Kim DJ, Shin J, Rajan S, Toh HT, Sohn M, Kim WG, Han M, Jeong I, Kim KS, Lee EH, TU, Y, Naffin-Olivos JL, Park CH, Ringe D, Yoon HS, Petsko GA, and Kim KS (2015) Agonists for Nurr1 enhance its contrasting dual functions and ameliorate Parkinson-related phenotypes. Proc. Natl. Acad. Sci. USA. 112, 8756-8761.