- BSc, Seoul National University
- MSc, Korea Advanced Institute of Science and Technology
- PhD, University of Chicago
- Researcher, Cancer Research Institute, Seoul National University, S. Korea
- Postdoctoral Fellow, Pharmaceutical Discovery Division, Abbott Laboratories, USA
- Research Scientist, Pharmaceutical Discovery Division, Abbott Laboratories, USA
- Sr. Research Scientist, Global Pharmaceutical R&D Division, Abbott Laboratories, USA
Apoptosis; Molecular chaperones in cancer, malaria, and neurodegenerative diseases; Peptidylprolyl cis-trans isomerase (PPIase); NMR; Structure-based drug design
Understanding molecular basis of proteins is a key to delineate their biological functions in cellular pathways and ultimately provides insights into therapeutic strategies in which aberrant expression of proteins is linked to underlying causes of diseases. We study the underlying molecular mechanisms of key regulatory proteins, characteristics of protein-protein and protein-ligand interactions by employing cross-disciplinary approaches including biochemical, biophysical, computational, and biological methods.
Over the years, our multidisciplinary research programmes enabled us to study molecular mechanisms of several key molecules involved in homeostatic regulation and signalling transduction pathways, such as phospholipid-interacting proteins, pro-survival Bcl-2 family proteins, and immunosuppressive drug FK506 binding proteins (FKBPs), and subsequently aided in developing their cognate ligands with therapeutic potential. The resulting outcomes provided us leverage to focus on translational biomedical research, in particular clinically unmet research areas, such as emerging pathogens and conformational disorders. Since the lead optimization and preclinical studies require inter-disciplinary approaches, we closely work with chemists and biologists. For long-term research goals, we’ll continue to focus on research projects addressing the fundamental molecular mechanisms of the anti-apoptotic proteins in homeostatic regulation, roles of immunophilins and immunophilin ligands in neuronal cells, immunophilin-mediated transcriptional regulation, molecular mechanism of vaccinia-related kinase 1 (VRK1)-mediated epigenetic regulation.