Wong, Esther

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Selected Publications

  1. Kaushik, S., Bandyopadhyay, U., Sridhar, S., Kiffin, R., Martinez-Vicente, M., Kon, M., Wong, E. and Cuervo, A.M. (2011) Chaperone-mediated autophagy at a glance. J. Cell Sci. 124, 495-499.
  2. Wong, E. and Cuervo, A.M. (2010) Integration of clearance mechanisms: the proteasome and autophagy. Cold Spring Harb. Perspect. Biol. doi:10.1101/cshperspect.a006734. (Morimoto, R., Kelly, J., Selkoe, D. ed.)
  3. Wong, E. and Cuervo, A.M. (2010)Neuronal autophagy gone awry: many fixings for the autophagic wrong-doing. Nat. Neurosci. 13, 805-811. (Selected for Issue cover)
  4. Martinez-Vicente, M.*, Talloczy, Z.*, Wong, E.*, Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D. and Cuervo, A.M. (2010) Cargo recognition failure is responsible for inefficient autophagy in Huntington’s Disease. Nat. Neurosci. 13(5), 567-576. (* equal contribution)
    • Highlighted in Research highlights: Ray, K. (2010) Neurodegenerative disease: “Empty” autophagosomes fail to carry their cargo in Huntington disease. Nat. Rev. Neurol. 6, 298.
    • Highlighted in Faculty of 1000 Medicine: Gu, X.F. and Yang,W. 7 May 2010.
  5. Lee, J-Y., Koga, H., Kawaguchi, Y., Tang, W., Wong, E., Gao, Y-S., Pandey, U.B., Kaushik, S., Tresse, E., Lu, J., Taylor, J.P., Cuervo, A.M. and Yao, T-P. (2010) HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality control autophagy. EMBO J. 29(5), 969-980.
  6. Cuervo, A.M., Wong, E. and Martinez-Vicente, M. (2010) Protein degradation, aggregation and misfolding. Mov. Disord. 25 Suppl. 1, S49-54.
  7. Wang, Y., Martinez-Vicente, M., Krϋger, U., Kaushik, S., Wong, E., Mandelkow, E.M., Cuervo, A.M. and Mandelkow, E. (2010) Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in cell model of pathological tau aggregation. Autophagy 6(1), 182-183.
  8. Wang, Y., Martinez-Vicente, M., Krϋger, U., Kaushik, S., Wong, E., Mandelkow, E.M., Cuervo, A.M. and Mandelkow, E. (2009) Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum. Mol. Genet. 18(21), 4153-4170. (Highlighted in Alzheimer Research Forum, 26 August 2009)
  9. Tan, J.M.M., Wong, E.S.P. and Lim, K.L. (2009)Protein misfolding and aggregation in Parkinson’s Disease. Antioxid. Redox Signal. 11(9), 2119-2134.
  10. Wong, E.S.P., Tan, J.M.M., Soong, W-E., Hussein, K., Nukina, N., Dawson, V.L., Dawson, T.M., Cuervo, A.M. and Lim, K.L. (2008) Autophagy-mediated clearance of aggresomes is not a universal phenomenon. Hum. Mol. Genet. 17(16), 2570-2582.
  11. Tan, J.M.M., Wong, E.S.P., Dawson, V.L., Dawson, T.M. and Lim, K.L. (2008) Lysine 63-linked ubiquitination potentially partners with p62 to promote the clearance of protein inclusions by autophagy. Autophagy 4, 251-253.
  12. Tan, J.M.M.*, Wong, E.S.P.*, Kirkpatrick, D.S., Pletnikova, O., Ko, H.S., Ho, M.W.L., Tay, S-P., Troncoso, J., Gygi, S.P., Lee, M.K., Dawson, V.L., Dawson, T.M. and Lim, K.L. (2008) Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum. Mol. Genet. 17(3), 431-439. (* equal contribution)
  13. Wong, E.S.P., Tan, J.M.M., Wang, C., Zhang, Z.S., Tay, S.P., Zaiden, N., Ko, H.S., Dawson, V.L., Dawson, T.M. and Lim, K.L. (2007) Relative sensitivities of parkin and other cysteine-containing enzymes to stress-induced solubility alterations. J. Biol. Chem. 282(16), 12310-12318.
  14. Wong, E., Yu, W.P., Yap, W.H., Venkatesh, B. and Soong, T.W. (2006) Comparative genomics of the human and Fugu voltage-gated calcium channel a1 -subunit gene family reveals greater diversity in Fugu. Gene 366(1), 117-127.
  15. Sriram, S.R., Li, X., Ko, H.S., Chung, K.K., Wong, E., Lim, K.L., Dawson, V.L. and Dawson, T.M. (2005) Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin. Hum. Mol. Genet. 14(17), 2571-2586.
  16. Wong, E., Ng, F.M., Yu, C.Y., Lim, P., Lim, L.H., Traynelis, S.F. and Low, C.M. (2005) Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor. Protein Sci. 14(9), 2275-2283.
  17. Sim, J., Wong, E., Chin, H.S. and Sim, T-S. (2003) Conserved structural modules and bonding networks in isopenicillin N synthase related non-heme iron-dependent oxygenases and oxidases. J. Mol. Cataly. B: Enzyme. 23, 17-27.
  18. Wong, E., Sim, J. and Sim, T-S. (2001) The invariant F283 and its strategic position in the hydrophobic cleft of Streptomyces jumonjinensis isopenicillin N synthase active site are functionally important. Biochem. Biophy. Res. Comm. 283, 621-626.
  19. Wong, E., Sim, J. and Sim, T-S. (2001) Construction of Streptomyces jumonjinensis isopenicillin N synthase double mutants, Ser119Ala/Glu120Gly and Thr308Ala/Thr309Val, overcomes insoluble expression in Escherichia coli. J. Mol. Cataly. B: Enzyme. 13: 17-25.