Davey, Curtis Alexander

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Selected Publications

  1. Z. Adhireksan*, G.E. Davey*, P. Campomanes*, M. Groessl, C.M. Clavel, H. Yu, A.A. Nazarov, C.H.F. Yeo, W.H. Ang, P. Dröge, U. Rothlisberger, P.J. Dyson & C.A. Davey.  2014.  Ligand Substitutions between Ruthenium-Cymene Compounds Can Control Protein versus DNA Targeting and Anticancer Activity.  Nature Commun.  10.1038/ncomms4462.
  2. C.A. Davey.  2013.  Does the Nucleosome Break Its Own Rules?  Curr. Opin. Struct. Biol.  23(2): 311-313.
  3. S.M. Meier, M. Hanif, Z. Adhireksan, V. Pichler, M. Novak, E. Jirkovsky, M.A. Jakupec, V.B. Arion, C.A. Davey, B.K. Keppler & C.G. Hartinger.  2013.  Novel Metal(II) Arene 2-Pyridinecarbothioamides: A Rational to Orally Active Organometallic Anticancer Agents.  Chem. Sci.  4(4): 1837-1846.
  4. E.Y.D. Chua*, D. Vasudevan*, G.E. Davey, B. Wu & C.A. Davey.  2012.  The Mechanics Behind DNA Sequence-Dependent Properties of the Nucleosome.  Nucleic Acids Res.  40(13): 6338-6352.
  5. B. Wu, G.E. Davey, A. Nazarov, P.J. Dyson & C.A. Davey.  2011.  Specific DNA Structural Attributes Modulate Platinum Anticancer Drug Site Selection and Cross-Link Generation.  Nucleic Acids Res39(18): 8200-8212.
  6. B. Wu*, M.S. Ong*, M. Groessl, Z. Adhireksan, C.G. Hartinger, P.J. Dyson & C.A. Davey.  2011.  A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core.  Chemistry.  17(13): 3562-3566.
  7. S. Tan & C.A. Davey.  2011.  Nucleosome Structural Studies.  Curr. Opin. Struct. Biol.  21(1): 128-136.
  8. A. Allahverdi, R. Yang, N. Korolev, Y. Fan, C.A. Davey, C.F. Liu & L. Nordenskiöld.  2010.  The Effects of Histone H4 Tail Acetylations on Cation-Induced Chromatin Folding and Oligomerization.  Nucleic Acids Res39(5): 1680-1691.
  9. M.S. Ong*, D. Vasudevan* & C.A. Davey.  2010.  Divalent Metal- and High Mobility Group N Protein-Dependent Nucleosome Stability and Conformation.  J. Nucleic Acids.  2010: 143890
  10. D. Vasudevan, E.Y.D. Chua & C.A. Davey.  2010.  Crystal Structures of Nucleosome Core Particles Containing the ‘601’ Strong Positioning Sequence.  J. Mol. Biol.  403(1): 1-10.
  11. K. Mohideen, R. Muhammad & C.A. Davey.  2010.  Perturbations in Nucleosome Structure from Heavy Metal Association.  Nucleic Acids Res38(18): 6301-6311.
  12. B. Wu & C.A. Davey.  2010.  Using Soft X-Rays for a Detailed Picture of Divalent Metal Binding in the Nucleosome.  J. Mol. Biol.  398(5): 633-640.
  13. B. Wu*, K. Mohideen*, D. Vasudevan & C.A. Davey.  2010.  Structural Insight into the Sequence Dependence of Nucleosome Positioning.  Structure.  18(4): 528-536.
  14. G.E. Davey*, B. Wu*, Y. Dong, U. Surana & C.A. Davey.  2010.  DNA Stretching in the Nucleosome Facilitates Alkylation by an Intercalating Antitumour Agent.  Nucleic Acids Res.  38(6): 2081-2088.
  15. B. Wu & C.A. Davey.  2008.  Platinum Drug Adduct Formation in the Nucleosome Core Alters Nucleosome Mobility but not Positioning.  Chem. Biol.  15(10): 1023-1028.
  16. G.E. Davey & C.A. Davey.  2008.  Chromatin– a New, Old Drug Target?  Chem. Biol. Drug Des.  72(3): 165-170.
  17. B. Wu, P. Dröge & C.A. Davey.  2008.  Site Selectivity of Platinum Anticancer Therapeutics.  Nature Chem. Biol.  4(2): 110-112. “Platinum Result” in Research Highlights.  2008.  Nature.  451(7175): 111.
  18. P. Dröge & C.A. Davey.  2008.  Do Cells let-7 Determine Stemness?  Cell Stem Cell.  2(1): 8-9.
  19. M.S. Ong, T.J. Richmond & C.A. Davey.  2007.  DNA Stretching and Extreme Kinking in the Nucleosome Core.  J. Mol. Biol.  368(4):  1067-1074.
  20. Q. Bao, H. Chen, Y. Liu, J. Yan, P. Dröge & C.A. Davey.  2007.  A Divalent Metal-mediated Switch Controlling Protein-induced DNA Bending.  J. Mol. Biol.  367(3):  731-740.
  21. O. Li, D. Vasudevan, C.A. Davey & P. Dröge.  2006.  High-Level Expression of DNA Architectural Factor HMGA2 and Its Association with Nucleosomes in Human Embryonic Stem Cells.  Genesis.  44(11):  523-529.
  22. T.J. Richmond & C.A. Davey.  2003.  The Structure of DNA in the Nucleosome Core.  Nature.  423(6936):  145-150.
  23. E. Eichhorn, C.A. Davey, D.F. Sargent, T. Leisinger & T.J. Richmond.  2002.  Crystal Structure of Escherichia coli Alkanesulfonate Monooxygenase SsuD.  J. Mol. Biol.  324(3):  457-468.
  24. C.A. Davey & T.J. Richmond.  2002.  DNA-Dependent Divalent Cation Binding in the Nucleosome Core Particle.  Proc. Natl. Acad. Sci. USA  99(17):  11169-11174. 
  25. C.A. Davey, D.F. Sargent, K. Luger, A.W. Mäder & T.J. Richmond.  2002.  Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1.9 Å Resolution.  J. Mol. Biol.  319(5):  1097-1113.
  26. C.A. Davey, T. Fiedler & R.E. Fenna.  2000.  Chap. 4"X-Ray Crystallographic Studies of Human Myeloperoxidase." in "The Peroxidase Multigene Family of Enzymes:  Biochemical Basis and Clinical Applications."  P.E. Petrides & W.M. Nauseef, Eds.  Springer-Verlag:  Berlin, New York.
  27. T.J. Fiedler, C.A. Davey & R.E. Fenna.  2000.  X-Ray Crystal Structure and Characterization of Halide-binding Sites of Human Myeloperoxidase at 1.8 Å Resolution.  J. Biol. Chem275(16):  11964-11971.
  28. C.A. Davey & R.E. Fenna.  1996.  2.3 Å Resolution X-Ray Crystal Structure of the Bi-Substrate Analogue Inhibitor Salicylhydroxamic Acid Bound to Human Myeloperoxidase:  A Model for a Pre-Reaction Complex with Hydrogen Peroxide.  Biochemistry35(33):  10967-10973.
  29. C. Davey, A. Jacquet, N. Moguilevsky & R.E. Fenna.  1995.  Characterization of the Heme-Protein Covalent Bonds in Human Myeloperoxidase by X-Ray Crystallography and Site Directed Mutagenesis.  Protein Engineering.  8(suppl.):  112.
  30. R. Fenna, J. Zeng & C. Davey.  1995.  Structure of the Green Heme in Myeloperoxidase.  Arch. Biochem. Biophys316:  653-656.