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Yu Chin-Wen, Kenneth

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Yu Chin-Wen, Kenneth

Yu Chin-Wen, Kenneth
Lecturer

Office: 02s-61
Telephone: 6316 2860
Email: CWYu@ntu.edu.sg

 

Education

  • Ph.D., University of Western Australia

Professional Experience

  • American Heart Association Postdoctoral Fellow, Division of Gastroenterology, Stanford University School of Medicine

Research Interest

One of my research areas is in the study of receptors involved in the metabolism of plasma lipoproteins, primarily chylomicron remnants, very-low-density-lipoproteins and low-density-lipoproteins. These lipoproteins are implicated in the pathogenesis of atherosclerosis whereby cholesterol deposits in the arteries of the heart may potentially cause heart attacks. In addition, I am interested in how dietary cholesterol carried by lipoproteins in the postprandial state are removed from the blood circulation by the liver. The specific research interests are as follows:

  • protein and gene expression of the LDL receptor and the LDL receptor-related protein in the arteries and the liver.
  • transcytosis of lipoproteins in the arterial wall.
  • sequestration mechanism for removal of chylomicron remnants in the liver.

Other research areas are:

  • Secretion of ApoE by macrophages: ApoE is a ligand for the cellular uptake of cholesterol-carrying lipoproteins via lipoprotein receptors. The specific research interest is identifying mechanisms of how macrophages "scavenge" cholesterol and the implication in atherosclerosis.
  • Secretion of ApoA1 by intestinal cells: ApoA1 is a protein that facilitates excretion of cholesterol from cells. The specific research interest is determining how dietary lipids influence the regulation of apoA1 in intestinal cells and how it impacts on cholesterol removal from the body.