Koh Cheng Gee

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Selected Publications

  1. Koon YL, Zhang S, Rahmat MB, Koh CG* and Chiam KH*. 2018 Enhanced Delta-Notch lateral inhibition model incorporating intracellular Notch herterogeneity and tension-dependent rate of Delta-Notch binding that reproduces spruting angiogenesis patterns. Scientific Reports. 8:9519. DOI:10.1038/s41598-018-27645-1. *corresponding authors,
  2. Ou S, Tan MH, Weng T, Li HY and Koh CG*. 2018. LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains. Open Biology. 8: 170202 doi: 10.1098/rsob.170202 
  3. Weng T and Koh CG*. 2017. POPX2 phosphatase regulates apoptosis through the TAK1-IKK-NFkB pathway. Cell Death & Disease. 8: e3051; doi 10.1038/cddis.2017.443
  4. Zhang S, Weng T, Guo T, Cheruba E, Chan H, Sze SK and Koh CG*. 2017. Phosphatase POPX2 exhibits dual regulatory functions in cancer metastasis. J Proteome Research. 16: 698-711
  5. Wong QY, Liu N, Koh CG, Li HY and Lew WS. 2016. Isolation of magnetically tagged cancer cells through an integrated magnetofluidic device. Microfluid Nanofluid. 20:139.
  6. Chuang LSH, Khor JM, Lai SK, Garg S, Krishnan V, Koh CG, Lee SH, Ito Y. 2016. Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progress. Proc Natl Acad Sci, USA. 113: 6490-6495 
  7. Hoon JL, Tan MH, and Koh CG*.  2016. The regulation of cellular responses to mechanical cues by Rho GTPases. Cells, 5: 17.
  8. Khaw SL, Chua MW, Koh CG*, Lim B and Shyh-Chang N*. 2015. Oocyte factors suppress mitochondrial polymucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Reports, 12:1080-1098. * corresponding authors. 
  9. Bernitt E, Koh CG, Gov N and Dobereiner HG. 2015. Dynamics of actin waves on patterned substrates: a quantitative analysis of circular dorsal ruffles. PLoS One 10: e0115857. 
  10. Hoon JL, Li HY and Koh CG*. 2014. POPX2 phosphatase regulates cell polarity and centrosome placement. Cell Cycle, 13: 2459-2468.
  11. Koon YL, Koh CG and Chiam KH. 2014 Computational modeling reveals optimal strategy for kinase transport by microtubules to nerve terminals. PLoS One 9(4): e92437.
  12. Phang HQ, Hoon JL, Lai SK, Zeng Y, Chiam KH, Li HY and Koh CG*. 2014. POPX2 phosphatase regulates the KIF3 kinesin motor complex. Journal of Cell Science, 127:727-739.
  13. Zhang S, Guo T, Chan H, Sze SK, and Koh CG*. 2013 An integrative transcriptome and proteome study to identify the signaling network regulated by POPX2 phosphatase. Journal of Proteome Research, 12: 2525-2536.
  14. Tay CY, Koh CG, Tan NS, Leong DT, and Tan LP. 2013 Mechano-regulation of stem cell fate via micro-nanoscale manipulation for regenerative medicine. Nanomedicine, 8:623-638.
  15. Chan KS, Koh CG* and Li HY*. 2012. Mitosis targeted anti-cancer therapies: where they stand. Cell Death and Disease. 3: e411. *corresponding authors.
  16. Hoon JL, Wong WK, and Koh CG*. 2012. Functions and regulation of circular dorsal ruffles. Molecular and Cellular Biology. 32: 4246-4257.
  17. Lee YP, Wong CH, Chan KS, Lai SK, Koh CG* and Li HY*.  2012. In vivo FRET revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase. PLoS One. 7: e45836. *corresponding authors.
  18. Dutta B, Adav SS, Koh CG, Lim SK, Meshorer E, Sze SK. 2012. Elucidating the temporal dynamics of chromatin associated protein release upon DNA digestion by quantitative proteomic approach. J. Proteomics. 75: 5493-5506.
  19. Heng YW, Lim HH, Mina T, Utomo P, Zhong S, Lim CT and Koh CG*. 2012. TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation. Journal of Cell Science, 125: 1579-1590.
  20. Zeng Y, Lai T, Koh CG, LeDuc PR, and Chiam KH. 2011. Investigating circular dorsal ruffles through varying substrate stiff ness and mathematical modeling. Biophysical Journal. 101:2121-2130 (I am the biologist in the team)
  21. Singh P, Gan CS, Guo T, Phang H-Q, Sze SK and Koh CG*. 2011. Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis. Proteomics, 11:2891-2900.  Featured article selected by the Editor.
  22. Heng YW and Koh CG*. 2010. Actin cytoskeleton dynamics and the cell division cycle. International Journal of Biochemistry and Cell Biology, 42: 1622-1633
  23. Susila, A, Chan H, Loh AXW, HQ Phang, ET Wong, Tergaonkar V and Koh CG*. 2010. POPX2, the negative regulator of the kinase PAK, regulates cancer cell motility and invasiveness. Cell Cycle, 9: 179-187. Featured in News and Views of the same issue.
  24. Wong CH, Chan H, Ho CY, Lai SK, Chan KS, Koh CG* & Hoi-Yeung Li*. 2009. Apoptotic histone modification inhibits nuclear transport by regulating RCC1. Nature Cell Biology, 11: 36-45. *corresponding authors. Featured in News and Views of the same issue.
  25. Tan TL, Fang N, Neo TL, Singh P, Zhang J, Zhou R, Koh CG, Chan V, Lim SG, and Chen WN. 2008. Rac1 GTPase is activated by hepatitis B virus replication-involvement of HBX. Biochemica et Biophysica Acta (BBA)-Molecular Cell Research, 1783: 360-74.
  26. Xie Y, Tan E-J, Wee S, Manser E, Lim L and Koh CG*. 2008. Functional Interactions between POPX2 phosphatase and mDia modulate RhoA pathways. Journal of Cell Science, 121:514-521.
  27. Koh CG*. 2007. Rho GTPases and their regulators in neuronal functions and development. NeuroSignals, 15: 228-237.
  28. Koh CG*, Tan E-J, Manser E, and Lim L. 2002. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Current Biology, 12: 317-321.
  29. Koh CG*, Manser E, Zhao Z-S, Ng C-P and Lim L. 2001. b1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles. Journal of Cell Science, 114: 4239-4251.
  30. Manser E, Loo T-H, Koh CG, Zhao Z-S, Chen X-Q, Tan L, Tan I, Leung T and Lim L. 1998. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Molecular Cell, 1: 183-192.
  31. Koh CG*, Oon S-H and Brenner, S. 1997. Serine/threonine phosphatases of the pufferfish, Fugu rubripes. Gene, 198: 223-228.
  32. Koh CG*, Barnett, L and Brenner, S. 1993. Vectorsl200g and l200c: two useful   derivatives of l2001.  Gene, 130: 117-119.
  33.